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Rabbit Anti-SCG5 Polyclonal Antibody#abs139208

Kindly note that the mentioned price is provided for your reference only. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis SCG5 using HeLa whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs139208-100ug	1-2 Weeks	301.0
abs139208-50ug	1-2 Weeks	201.0

Kindly note that the mentioned price is provided for your reference only. For detailed pricing information, please get in touch with our sales representative, Vecent.

Overview
catalog	abs139208
Other names	The 7B2 protein, also known as Secretory granule neuroendocrine protein 1, is a vital molecule in the regulation of hormone secretion in the body. It is a Prohormone convertase chaperone that assists in the proper processing and activation of prohormones, which are precursors to the final active hormones. This protein is found in secretory granules in various endocrine and neuroendocrine cells, such as the pituitary gland and gut endocrine cells. Scientific studies have identified several isoforms of this protein, including Secretogranin5, Secretogranin V, and Pituitary polypeptide. It is believed that these isoforms have distinct functions, such as regulation of gene expression and secretion of hormones in different types of cells. This protein plays a key role in the proper functioning of the endocrine system and regulating the body's physiological processes. In addition to its important role in hormone secretion, 7B2 is also involved in other cellular processes. For example, it acts as a modulator of calcium signaling and contributes to the overall response of cells to external stimuli. As a result, disturbances in 7B2 levels or function can lead to various diseases and disorders. Overall, understanding the mechanisms underlying the regulation of the 7B2 protein is crucial for the development of new therapies for endocrine disorders and other diseases related to hormone imbalances.
Source	Rabbit
Specificity	The SCG5 Antibody can detect the complete amount of SCG5 that exists naturally within an organism. It is able to identify the endogenous levels of total SCG5, accurately and efficiently. This data can be used for further analysis and research, providing scientists with a deeper understanding of biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Sheep;Dog;Horse;Bovine;
Antigen	SCG5
Application	WB1:1000-3000，（IHC），1:200。ELISA（），1:20000-1:40000。。
Immunogen	A synthesized peptide derived from human SCG5.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed in purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the item in a freezer at -20°C for up to one year. It is vital to avoid defrosting and refreezing the product repeatedly.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Posttranslational modification	Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.Sulfated on tyrosine residues.
Celluar localization	Extracellular region or secreted;
UniPort	P05408