Rabbit Anti-Dynamin1 Polyclonal Antibody#abs131153

abs131153-50ug

1-2 Weeks

201

abs131153-100ug

1-2 Weeks

301

Description

SNX9 is a protein that facilitates the production of microtubule bundles and also functions as a microtubule-associated force producer. It has the ability to bind and hydrolyze GTP, and is primarily involved in vesicular trafficking processes within cells. Furthermore, this protein plays an important role in receptor-mediated endocytosis and is known to regulate dynamin assembly. In particular, SNX9 is required for efficient clathrin-mediated endocytosis, which is crucial to multiple cellular functions. Overall, SNX9 is a highly important cellular protein with a wide range of functions critical to the normal functioning of cells.

Other names

Dynamin, also known as DNM1 or D100, is a protein that belongs to the family of dynamin GTPases. This protein plays a critical role in various cellular processes, such as endocytosis, vesicle trafficking, and membrane dynamics. Dynamin is encoded by the DNM1 gene and is expressed in many tissues throughout the body.
Some other names for dynamin include B dynamin, DNM, and Dynamin-1. This protein is highly conserved across species and has been extensively studied in various model organisms, including mice, flies, and worms.
One of the key functions of dynamin is to promote membrane fission, which occurs when a vesicle is released from a parent membrane. Dynamin accomplishes this by assembling into helical structures around the neck of the vesicle and constricting it until it breaks free. This process is essential for many cellular functions, such as neurotransmitter release, receptor downregulation, and nutrient uptake.
Dynamin dysfunction has been implicated in a variety of diseases, including Alzheimer's, epilepsy, and hypertension. Therefore, understanding the molecular details of dynamin function has important implications for the development of new therapies for these conditions.

Source

Rabbit

Specificity

The total Dynamin 1 protein levels can be detected by the antibody, indicating its ability to recognize endogenous forms of the protein.

Application

，，。 WB 1:500-1:1000，ELISA（）1:20000-1:40000。

One possible rearrangement of the peptide sequence around aa.774~778 (S-P-T-S-S) derived from Human Dynamin 1 could be:
S-S-T-P-S
This new sequence still contains the same five amino acids as the original one, but in a different order. The first and last residues have switched places, while the middle three are still together. This rearrangement might result in a slightly altered function or interaction of the dynamin protein, depending on the specific context and downstream effects of this peptide sequence. However, without more information about the protein and its molecular environment, it is difficult to say exactly what would change.

Properties

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To ensure maximum efficiency, the resin was specifically designed for use in this process. The resulting product is a highly purified antiserum, ready for use in a variety of applications.

Clonality

Polyclonal Antibody

To maintain quality, it is advised to store at -20 °C for a duration of one year. It is important to avoid subjecting the substance to multiple freeze-thaw cycles.

Storage buffer

Our rabbit IgG is formulated in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store the product at -20 °C for optimal stability. Please note that the stability period of the product is 12 months from the date of receipt.

Target

Background

This protein is a powerful force producer that works in tandem with microtubules to create bundles and has the ability to bind and hydrolyze GTP. It plays an important role in various vesicular trafficking processes. Specifically, this protein is involved in receptor-mediated endocytosis, facilitating the uptake of molecules from the extracellular space into the cell.

Celluar localization

Q05193