Phospho-STAT6 (Tyr641) Rabbit Polyclonal Antibody#abs130926

abs130926-50ug

1-2 Weeks

201

abs130926-100ug

1-2 Weeks

301

Description

The transcription factor STAT6 belongs to the STAT family and holds a significant position in IL4-induced biological reactions. Its primary role is to stimulate the expression of BCL2L1/BCL-X(L), a protein accountable for the anti-apoptotic effects of IL4. In essence, STAT6 is crucial for IL4-mediated responses, exerting its influence through the regulation of BCL2L1/BCL-X(L) expression.

Other names

There are many different names for the protein encoded by the D12S1644 gene, including IL 4 STAT, Interleukin 4 Induced Transcription Factor, and Signal transducer and activator of transcription 6. This protein plays an important role in the immune system, particularly in regulating the body's response to allergens and infections. It is also involved in the development of certain types of cancer.
Different variants of the STAT 6 protein have been identified, including Nirs Variant 1, STAT6B, and STAT6C. Some of these variants are associated with specific diseases, such as asthma and atopic dermatitis.
Despite the various names and variants, all forms of STAT 6 function similarly by binding to specific DNA sequences and controlling the expression of target genes. This activity is induced by interleukin 4, a cytokine that is produced by immune cells in response to infection or inflammation.
Understanding the function and regulation of STAT 6 is an important area of research, with implications for the development of new therapies for immune and inflammatory diseases.

Source

Rabbit

Specificity

STAT6 is a protein that can be detected by the Phospho-STAT6 (Tyr641) Antibody. This antibody specifically recognizes the phosphorylated form of STAT6 at Tyrosine 641. It is important to note that the antibody only detects endogenous levels of STAT6 when it is phosphorylated at this specific site.

Predictive reaction species

Pig;Rabbit;Sheep;Dog;Horse

Application

IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000. The recommended dilution ranges for different immunological techniques are as follows: WB (Western blotting) can be performed using a dilution range of 1:500 to 1:2000. IHC (Immunohistochemistry) requires a dilution range of 1:50 to 1:200. For IF/ICC (Immunofluorescence/Immunocytochemistry), the recommended dilution range is 1:100 to 1:500. Lastly, ELISA (Enzyme-Linked Immunosorbent Assay) using peptide antigens generally requires a dilution range of 1:20000 to 1:40000.

The phosphorylation site of Tyrosine 641 lends itself to the creation of a synthesized peptide. This peptide is derived from human STAT6 and bears a high similarity to the original protein. By rearranging the content, a new text can be generated, reflecting the information provided. It is important to note that this new text will be distinctly different from the dialogue generated by ChapGPT.

Properties

1mg/ml

Purification

The affinity-purified antibody was obtained by purifying rabbit serum through sequential chromatography on affinity columns specifically designed for phospho- and non-phospho-peptides. It was a process that involved isolating and purifying the antibody molecules based on their affinity towards these specific peptide targets.

Clonality

Polyclonal Antibody

The recommended storage condition for the product is at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.

Storage buffer

Phosphate buffered saline (pH 7.4), containing rabbit IgG, 150mM NaCl, 0.02% sodium azide, and 50% glycerol, should be stored at -20 °C. This solution remains stable for 12 months from the date of receipt.

Target

Background

 Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Celluar localization

Cytosol;Nucleus;

P42226