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Rabbit Anti-CD320 Polyclonal Antibody#abs138430

Description

Catalog-specification	Delivery time	USD price
abs138430-100ug	1-2 Weeks	301.0
abs138430-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138430
Other names	The 8D6 antigen, also known as CD320 or FDC-SM-8D6, is a crucial molecule involved in FDC signaling. It is also referred to as TCblR, short for transcobalamin receptor. CD320_HUMAN is the designated name for the CD320 antigen in humans. The 8D6A variant is another form of the 8D6 antigen. The function of CD320 is critical in facilitating the uptake of transcobalamin-bound vitamin B12 by cells. CD320 has garnered significant attention due to its role in various physiological processes. Understanding the intricate mechanisms and importance of CD320 aids in the advancement of research in related fields.
Source	Rabbit
Specificity	CD320 antibody is used to identify the levels of total CD320 protein in biological samples. It specifically recognizes the endogenous levels of CD320.
Species Reactivity	Human;Mouse;Rat
Antigen	CD320
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CD320.
MW	29kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was carried out using SulfoLink™ Coupling Resin through peptide affinity chromatography. The resin enabled efficient binding of the target peptide, resulting in high purity of the final product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum effectiveness, it is suggested that this product be stored at a temperature of -20 °C for a duration of one year. It is advisable to avoid exposing the product to repeated freeze/thaw cycles, which may impact its quality and efficacy over time.
Storage buffer	This product contains rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and is stable for 12 months from the date of receipt. For optimal preservation, please ensure that it is stored properly.
Target
Background	CD320 is a plasma membrane protein that plays an important role in cobalamin uptake by acting as a receptor for transcobalamin saturated with cobalamin (TCbl). It is primarily expressed on follicular dendritic cells (FDC) and interacts with germinal center B cells to promote their differentiation and proliferation. In addition to its role in costimulating B cell responses to antigenic stimuli, CD320 also augments the proliferation of plasma cell precursors generated by IL-10. GC-B cells differentiate into memory B-cells and plasma cells through interaction with T-cells and FDC, highlighting the crucial role of CD320 in adaptive immunity. Overall, CD320 is a vital player in the complex and intricate network of immune system regulation and function.
Tissue specificity	Detected in the germinal center (GC) of lymphoid follicles (at protein level) (PubMed:11418631). Expressed abundantly on follicular dendritic cells (FDCs) (PubMed:10727470).
Celluar localization	Endoplasmic reticulum;Endosome;Extracellular region or secreted;Plasma Membrane;
UniPort	Q9NPF0