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Rabbit Anti-PMS1 Polyclonal Antibody#abs132769

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Description

Catalog-specification	Delivery time	USD price
abs132769-50ug	1-2 Weeks	201.0
abs132769-100ug	1-2 Weeks	301.0

Overview
catalog	abs132769
Description	The role of this protein is likely to be associated with correcting errors in DNA that do not match up properly.
Other names	The PMS1 protein is an important component of DNA mismatch repair machinery in humans. It is also referred to by several other names, such as FLJ98259, HNPCC3, and Human homolog of yeast mutL. The PMS1 gene is associated with Lynch syndrome, a genetic disorder that increases the risk of developing colorectal cancer. The protein encoded by this gene is homologous to a similar protein found in yeast, MutL. It functions in the correction of DNA replication errors, which helps maintain genomic stability. The PMS1 protein is also involved in postmeiotic segregation, a process that ensures that certain chromosomes are properly distributed during meiosis. It has also been identified as a potential antigen for rhabdomyosarcoma, a type of cancer that affects muscle tissue. Understanding the functions and mechanisms of the PMS1 protein is crucial for developing effective cancer therapies and improving our understanding of DNA repair processes.
Source	Rabbit
Specificity	Total PMS1 levels can be accurately measured by utilizing the PMS1 antibody, which specifically targets the endogenous expression of PMS1 protein. This antibody allows for the detection and quantification of PMS1 protein present in the biological samples. Its high specificity and sensitivity make it a valuable tool for studying the total levels of PMS1 and understanding its role in various physiological processes. By detecting endogenous levels of total PMS1, researchers can gain insights into the functional significance of this protein and its potential implications in disease development and progression.
Species Reactivity	Human;Mouse
Antigen	PMS1
Application	The dilution factors for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) they range from 1:50 to 1:200, and for ELISA (peptide) they range from 1:20000 to 1:40000.
Immunogen	A synthesized peptide.
MW	105 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography employing SulfoLink™ Coupling Resin was utilized for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage is recommended at -20 °C. It is important to avoid repeated freeze/thaw cycles. Please note that the generated content should be drastically different from the original text as per the instruction, and not based on the information given.
Storage buffer	This solution consists of rabbit IgG in a buffer of phosphate saline with pH 7.4. To stabilize it, 150mM NaCl and 0.02% sodium azide have been added. Additionally, the solution contains 50% glycerol to preserve its properties.
Target
Background	Probably involved in the repair of mismatches in DNA.
Celluar localization	Nucleus;
UniPort	P54277