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Rabbit Anti-PHLDA3 Polyclonal Antibody#abs132768

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Description

Catalog-specification	Delivery time	USD price
abs132768-100ug	1-2 Weeks	301.0
abs132768-50ug	1-2 Weeks	201.0

Overview
catalog	abs132768
Description	Akt1 signaling is repressed by p53/TP53, a tumor suppressor protein. One way p53/TP53 achieves this repression is by preventing Akt1 from binding to membrane lipids, effectively inhibiting its translocation to the cellular membrane and subsequent activation. This inhibition of Akt1 activity contributes to p53/TP53-dependent apoptosis, as it serves to counteract the pro-survival effects mediated by Akt1. The specific mechanism by which p53/TP53 regulates Akt1 through transcriptional control may provide insights into how p53/TP53 exerts a negative regulatory influence on Akt1. Overall, this repression of Akt1 by p53/TP53 indicates a potential role for p53/TP53 as a tumor suppressor, highlighting its involvement in limiting pro-survival signaling pathways associated with cancer development.
Other names	The protein known as PHLDA3, or Pleckstrin homology like domain family A member 3, is also referred to as PHLA3 or Pleckstrin homology like domain family A member 2. It is also sometimes called TDAG51/Ipl homolog 1 or TIH1. This protein belongs to the Pleckstrin homology-like domain family A and has been found to have a role in regulating cellular processes, including apoptosis, proliferation, and differentiation. Despite its various names, PHLDA3 is used commonly in scientific literature to refer to this important regulatory protein.
Source	Rabbit
Specificity	The endogenous levels of total PHLDA3 can be detected using the PHLDA3 antibody. Would you like me to provide more information about the application or benefits of this antibody?
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	PHLDA3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	14 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. We were able to obtain a highly purified antiserum through this process.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Tissue specificity	Widely expressed with lowest expression in liver and spleen.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9Y5J5