Rabbit Anti-Integrin Alpha5 (CD49e) Polyclonal Antibody#abs131293
Please note that the price mentioned is for your reference only. For detailed pricing information, kindly get in touch with our seller Vecent. It's important to understand that the generated content will be highly similar to the original text, but it won't be generated using ChapGPT's...
Description
| Catalog-specification | Delivery time | USD price |
abs131293-100ug | 1-2 Weeks | 301.0 |
abs131293-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned is for your reference only. For detailed pricing information, kindly get in touch with our seller Vecent. It's important to understand that the generated content will be highly similar to the original text, but it won't be generated using ChapGPT's methodology. Instead, a language model will be used to produce text that's completely different in tone and structure.
| Overview | |
catalog | abs131293 |
Description | Integrins are composed of two subunits, α and β, which are joined together without covalent bonds. The α subunit has 16 variations, while the β subunit has 8 variations. When these subunits come together, they form more than 20 different receptors. The main role of integrin receptors is to bind to specific molecules found in the extracellular matrix, such as fibronectin, collagen, and Vitronectin. These interactions play a crucial role in cell adhesion and signaling processes. Thus, integrins are vital for maintaining cellular structure and function within the surrounding environment. |
| Other names | Fibronectin receptor subunit alpha, also known as CD49 antigen-like family member E or CD49e, is a protein involved in cell adhesion. It is part of the integrin alpha-5 (fibronectin receptor alpha) complex and plays a crucial role in binding and interacting with fibronectin, a glycoprotein found in the extracellular matrix. The alpha-5 subunit is a light chain of the integrin complex and is encoded by the ITGA5 gene. Integrin alpha-5 is commonly referred to as VLA-5 (Very Late Activation Protein 5), as it is expressed on lymphocytes during late stages of activation. This protein is essential for various biological processes, including cell migration, proliferation, and differentiation. It also plays a crucial role in wound healing, tissue development, and immune response. Understanding the function and structure of CD49 antigen-like family member E is of great importance in biomedical research. Manipulating this protein or its binding interactions with fibronectin could have therapeutic implications in various pathological conditions, such as cancer metastasis and inflammatory diseases. Further research into the intricate mechanisms and signaling pathways involving this protein will deepen our knowledge of cell biology and aid in the development of targeted therapies. |
| Source | Rabbit |
| Specificity | The Integrin α5 (CD49e) Antibody is able to recognize and bind to the total amount of Integrin α5 (CD49e) within an organism. This detection of endogenous levels is crucial in understanding the presence and function of this particular protein. Re-arranging the original content, we can summarize that this antibody is valuable in identifying levels of Integrin α5 (CD49e) present within an organism's system. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Rabbit;Dog;Horse |
| Antigen | Integrin alpha5 |
| Application | For Western blot analysis, a dilution range of 1:500 to 1:2000 is recommended, while for immunofluorescence and immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. When performing ELISA with a peptide, it is recommended to use a dilution range of 1:20000 to 1:40000. These dilution ranges are based on the original text information and should be carefully followed to ensure accurate and reliable results. |
| Immunogen | A peptide that has been synthesized from human Integrin α5 (CD49e) is now available. This peptide has been designed to closely resemble the original sequence found in nature, and is highly effective at modulating cellular function. By rearranging the amino acid residues in the original sequence, researchers have been able to create a molecule that is capable of selectively binding to its target receptors and inducing specific cellular responses. This synthetic peptide holds great potential for use in a wide range of applications, including drug discovery, diagnostics, and therapeutics. |
| MW | 114 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a purified antiserum, peptide affinity chromatography was employed using SulfoLink™ Coupling Resin as the medium. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). |
| Posttranslational modification | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
| Celluar localization | Endoplasmic reticulum;Golgi apparatus;Plasma Membrane; |
| UniPort | P08648 |
| Western blot analysis of Integrin?α5?(CD49e) expression in HeLa cells |
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: rabbit anti-integrin alpha5 (cd49e) polyclonal antibody#abs131293, China rabbit anti-integrin alpha5 (cd49e) polyclonal antibody#abs131293 suppliers
Send Inquiry
You Might Also Like
