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Rabbit Anti-caspase12 Polyclonal Antibody#abs131292

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Description

Catalog-specification	Delivery time	USD price
abs131292-100ug	1-2 Weeks	301.0
abs131292-50ug	1-2 Weeks	201.0

Overview
catalog	abs131292
Description	This protein does not possess any protease activity and has been observed to have potential in reducing the release of cytokines that occur in response to bacterial lipopolysaccharides during infections. It also exhibits the ability to decrease the activation of NF-kappa-B stimulated by TNF, which suggests a role in regulating inflammation. Overall, this protein has promising therapeutic implications in managing inflammatory responses and related conditions.
Other names	Caspase 12, also known as CASP 12 or CASP-12, is a gene/pseudogene that plays a role in apoptosis. It is responsible for the activation of caspases, which are enzymes involved in cell death processes. CASP12P1 is the specific pseudogene 1 isoform of caspase 12. In humans, the caspase 12 protein is inactive. It is encoded by the CASPC_HUMAN gene, and its corresponding sequence is identified as OTTHUMP00000207032.
Source	Rabbit
Specificity	Total caspase12 can be detected using the caspase12 Antibody, which targets endogenous levels of the protein.
Species Reactivity	Human
Antigen	caspase12
Application	To ensure optimal results, we recommend using WB at a dilution of 1:500-1:2000, IHC at 1:50-1:200, and ELISA with a peptide substrate at a dilution of 1:20000-1:40000. By following these dilution guidelines, you can effectively detect the protein of interest in your samples. It is important to note that individual experiments may require slight adjustments to these dilutions based on specific conditions and sample types. Overall, careful optimization of your assay conditions will lead to reliable and reproducible data.
Immunogen	A peptide synthesized from caspase12 in the human body has been created. The peptide is derived from the original human caspase12 and is highly similar to it. Through rearranging the content of the original text, a new content is generated, which is based on the same information provided in the original text.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To do so, this process was utilized, resulting in the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to note that repeated cycles of freezing and thawing should be avoided to prevent damage to the product. Hence, it is important to handle and store the product with care to maintain its efficacy.
Storage buffer	This product contains Rabbit IgG in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and remains stable for 12 months from the date of receipt.
Target
Background	Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Tissue specificity	Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
Celluar localization	Endoplasmic reticulum;
UniPort	Q6UXS9