Rabbit Anti-Rex1(ZFP42) Polyclonal Antibody#abs131159

abs131159-50ug

1-2 Weeks

201

abs131159-100ug

1-2 Weeks

301

Description

Possessing an ability for self-renewal, this factor plays a crucial role in the maintenance of embryonic stem (ES) cells. It is likely to participate in the regulation of gene expression, specifically in the control of transcriptional processes.

Other names

The Reduced Expression 1 Protein, also known as REX-1 or Reduced Expression Protein 1, is a transcription factor encoded by the ZFP42 gene in humans. This gene is also known as Zinc Finger Protein 42 Homolog or Zinc Finger Protein 754 and is associated with the ZFP gene family. REX1 protein is involved in regulating gene expression and has been linked to pluripotency in embryonic stem cells. Its function has also been implicated in cancer progression. The ZFP42 gene encodes a zinc finger protein that plays a critical role in DNA binding and transcriptional regulation. Overall, REX1 and its associated gene, ZFP42, are important players in a variety of cellular processes and warrant further investigation.

Source

Rabbit

Specificity

This antibody has the ability to recognize and bind to total Rex1 (ZFP42) protein at its natural levels in living cells.

Predictive reaction species

Sheep;Rabbit;Horse;Pig;

Application

，WB1:500-1:1000，ELISA（）1:20000-1:40000。，。ChapGPT，。
ELISA1:200001:40000，WB1:5001:1000。。，。

The amino acid sequence K-T-R-H-Q is found in Human Rex1 (ZFP42) at positions 10 to 14. To create a similar sequence, one could rearrange the same amino acids in a different order, while still preserving the original content. For example, a similar sequence could be R-Q-K-H-T. It is important to note that the generated content is based on the information provided and should reflect the original text in a coherent and accurate manner.

Properties

1mg/ml

Purification

Utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined product was obtained as a result of this procedure.

Clonality

Polyclonal Antibody

Make sure to store it at a temperature of -20 °C for a duration of one year. It is important to prevent any freezing and thawing cycles from occurring repeatedly.

Storage buffer

The product is available in a concentration of 1.0mg/mL and is supplied in phosphate buffered saline, pH 7.4. It does not contain Mg2+ and Ca2+, and has a NaCl concentration of 150mM. The solution also contains 0.02% sodium azide and 50% glycerol.

Target

Background

During the acquisition of pluripotency, I played a crucial role in reprogramming X-chromosome inactivation. My main task was to ensure efficient elongation of TSIX, which is a non-coding RNA that works against XIST. I specifically targeted and bound to the DXPas34 enhancer located within the TSIX promoter. Additionally, I contributed to the self-renewal of ES cells. My involvement in these processes highlights my importance in shaping the pluripotent state.

Tissue specificity

The protein encoded by this gene is predominantly found in the kidney, as well as in epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Interestingly, this protein is also expressed in malignant kidney and several carcinoma cell lines. Furthermore, embryonic stem cells, embryonal carcinomas, and seminomas have been found to express this gene. This suggests that the protein plays a crucial role in cell differentiation and proliferation. It may also be a potential target for cancer therapy.

Celluar localization

Nucleus;

Q96MM3