Rabbit Anti-I-TRAF Polyclonal Antibody#abs131395
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Description
| Catalog-specification | Delivery time | USD price |
abs131395-100ug | 1-2 Weeks | 301.0 |
abs131395-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. It is important to emphasize that the content generated should be based on the original text information while rearranging the wording. To avoid relying on a dialogue format similar to ChapGPT, kindly generate the text in a manner that is distinctly different but still logical.
| Overview | |
catalog | abs131395 |
Description | Its primary function involves regulating the activity of TRAF proteins by maintaining them in an inactive state. When there is an overexpression of this regulator, it effectively suppresses the NF-kappa-B activation mediated by TRAF2, which is initiated by the receptors CD40, TNFR1, and TNFR2. Additionally, it hinders the binding of TRAF2 to LMP1 and consequently inhibits the NF-kappa-B activation triggered by LMP1. This regulator may also play a role in regulating I-kappa-B-kinase (IKK) activity by acting as an adapter for kinases like TBK1 or IKBKE, which have the ability to modulate IKK activity. |
| Other names | The TRAF family member-associated NF-kappa-B activator, also known as TRAF-interacting protein (TANK), plays a critical role in activating the NF-kappa-B signaling pathway. TANK interacts with members of the TRAF family, such as TRAF2, to promote the activation of NF-kappa-B. It is also referred to as Tank, Tank_Human, ITRAF, or I-TRAF. There are two isoforms of TANK, namely isoform a and isoform b. TANK is an important mediator in the regulation of immune responses and inflammation through its interaction with TRAF proteins. |
| Source | Rabbit |
| Specificity | The I-TRAF Antibody is capable of identifying total I-TRAF levels within an organism. This antibody is specifically designed to detect endogenous levels of I-TRAF, providing researchers with valuable insights into the protein's role in various biological processes. By rearranging the original content, we can convey the same message in a slightly different manner. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Sheep;Dog;Bovine;Horse |
| Antigen | I-TRAF |
| Application | The recommended dilution for WB is 1:500 to 1:2000, while IF/ICC requires a dilution of 1:100 to 1:500. For ELISA using peptide, the suggested dilution range is 1:20000 to 1:40000. These are crucial guidelines that need to be followed to obtain accurate and reproducible results. It's essential to maintain consistent dilution ratios to avoid any errors and deviations in your experiments. By following these recommendations, researchers can ensure that their experiments generate robust and reliable data. |
| Immunogen | A synthesized peptide derived from human I-TRAF. |
| MW | 47 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a pure antiserum, we employed the SulfoLink™ Coupling Resin in peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. |
| Tissue specificity | Ubiquitous. |
| Posttranslational modification | Phosphorylated by IKBKE. |
| Celluar localization | Cytosol; |
| UniPort | Q92844 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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