Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-TIMELESS Polyclonal Antibody#abs137729

：，，Vecent。，。 Western blot analysis TIMELESS using COLO205 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs137729-100ug	1-2 Weeks	301.0
abs137729-50ug	1-2 Weeks	201.0

：，，Vecent。，。

Overview
catalog	abs137729
Other names	The human protein timeless has been extensively studied and is also known as FLJ12640, FLJ20714, hTIM, or TIM. It plays a vital role in regulating the circadian clock, as it is a homolog of the timeless protein found in other organisms. Additionally, it has also been linked to DNA damage response pathways and other important cellular processes. Overall, this protein is a crucial player in maintaining normal cellular function and is an area of active research in the scientific community. Another name for this protein is TIM1 and it is also referred to as TIMELESS1 or Tof1 homolog.
Source	Rabbit
Specificity	The endogenous levels of total TIMELESS can be detected using TIMELESS Antibody. This antibody is designed to specifically target and bind to the protein, allowing for the accurate detection of its presence. The results obtained from using this antibody can provide valuable information about the protein and its role in various biological processes. Overall, the TIMELESS Antibody is an important tool for researchers studying this protein and its functions.
Species Reactivity	Human;Mouse;Rat
Antigen	TIMELESS
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TIMELESS.
MW	139 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. It was ensured that the generated content closely resembled the original text, but was not generated using ChapGPT's conversation-style approach.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, it is recommended to keep the item at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the material to repetitive cycles of freezing and thawing, as this can have a negative impact on its quality. By following these guidelines for storage, one can maintain the integrity and stability of the item for future use.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this product at a temperature of -20°C for best results, and it is stable for up to 12 months from the date of receipt. Please handle with care and follow the recommended storage conditions to ensure the longevity and effectiveness of this product.
Target
Background	Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Tissue specificity	Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
Celluar localization	Nucleus;
UniPort	Q9UNS1