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Rabbit Anti-SYNGAP1 Polyclonal Antibody#abs137319

Please note that the price provided above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Thank you. Western blot analysis SYNGAP1 using HeLa whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs137319-100ug	1-2 Weeks	301.0
abs137319-50ug	1-2 Weeks	201.0

Please note that the price provided above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Thank you.

Overview
catalog	abs137319
Other names	DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; OTTHUMP00000064825; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RASA 5; RASA1; RASA5; SYGP1_HUMAN; Synaptic Ras GAP 1; Synaptic Ras GTPase activating protein 1; Synaptic Ras GTPase activating protein 1 homolog; Synaptic Ras GTPase activating protein 135kDa; Synaptic Ras GTPase activating protein; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP 1; SYNGAP1; Here are some rearranged versions of the above content: 1. SYNGAP1, also known as DKFZp761G1421 or KIAA1938, is a neuronal Ras GTPase activating protein. It is also referred to as MRD5 or p135 SynGAP. The protein functions as a synaptic Ras GAP 1, playing a role in regulating the activity of Ras GTPases. Its molecular weight is approximately 135kDa. SYNGAP1 is an important component of synaptic signaling and is associated with conditions such as RASA1 and RASA5. 2. RASA1, RASA5, or SYNGAP1, also known as DKFZp761G1421 or KIAA1938, is a synaptic Ras GAP 1 protein. It acts as a Ras GTPase activating protein, regulating the activity of Ras GTPases in neurons. SYNGAP1 is involved in synaptic signaling and has a molecular weight of around 135kDa. It is also referred to as MRD5 or p135 SynGAP and plays a crucial role in conditions such as neuronal RasGAP and OTTHUMP00000064825. 3. SYNGAP1, also called RASA1 or RASA5, is a synaptic Ras GTPase activating protein 1. It is known to regulate the activity of Ras GTPases in neurons and is involved in synaptic signaling. SYNGAP1, with a molecular weight of approximately 135kDa, is also referred to as DKFZp761G1421 or KIAA1938. Other names include MRD5, p135 SynGAP, and OTTHUMP00000064825. SYNGAP1 is a critical component in neuronal RasGAP and plays a crucial role in neuronal function.
Source	Rabbit
Specificity	The detection of endogenous levels of total SYNGAP1 can be achieved using the SYNGAP1 Antibody. This antibody specifically binds to the SYNGAP1 protein, allowing for the accurate measurement of its presence in biological samples. It is important to note that the SYNGAP1 Antibody is capable of detecting the total amount of SYNGAP1, including all isoforms and modifications. By utilizing this antibody in various assays, researchers can gain insights into the expression and regulation of SYNGAP1 in different physiological and pathological conditions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	SYNGAP1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SYNGAP1.
MW	147 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the material to repeated freeze/thaw cycles, as this can compromise the integrity of the sample. Take care to adhere to these guidelines to ensure the longevity and quality of the stored material.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
Posttranslational modification	Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q96PV0