Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PKP3 Polyclonal Antibody#abs137787

Description

Catalog-specification	Delivery time	USD price
abs137787-100ug	1-2 Weeks	301.0
abs137787-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference purposes only. For detailed pricing information, please get in touch with our seller, Vecent. It is important to understand that the actual price may vary based on specific requirements and other factors. Therefore, we recommend reaching out to our seller to obtain accurate pricing information and to discuss any questions or concerns you may have. Thank you for considering our services.

Overview
catalog	abs137787
Other names	The protein PKP3, also known as plakophilin-3, is an important component of adherens junctions in various tissues throughout the human body. It is encoded by the PKP3 gene, and several isoforms, including PKP3b, have been identified. PKP3 plays a critical role in maintaining the structural integrity and stability of these junctions and contributes to the regulation of cytoskeletal dynamics. Mutations or dysregulation of PKP3 expression have been linked to several diseases, including cardiovascular disorders and cancer. A better understanding of the functions of PKP3 and its interaction with other proteins may lead to new therapies for these conditions.
Source	Rabbit
Specificity	The PKP3 Antibody has the ability to identify the total amount of endogenous PKP3 present in a sample. This information can be useful in analyzing the expression and function of PKP3 protein in biological systems. Similar content can be created by rephrasing the original text while maintaining the relevant information.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	PKP3
Application	The dilution recommendation for WB is between 1:1000 and 3000, while for IHC it is 1:200. For ELISA using peptide, a dilution ratio of 1:20000 to 1:40000 is recommended. It is important to note that these dilutions are based on the original text information and should be followed accordingly.
Immunogen	A synthesized peptide derived from human PKP3.
MW	87 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, it is recommended to store the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of this product is guaranteed for 12 months starting from the date of receipt.
Target
Background	May play a role in junctional plaques.
Tissue specificity	Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	Q9Y446