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Rabbit Anti-DAB2 Polyclonal Antibody#abs137269

Description

Catalog-specification	Delivery time	USD price
abs137269-100ug	1-2 Weeks	301.0
abs137269-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137269
Other names	DAB 2, also known as Differentially Expressed in Ovarian Cancer 2, or Disabled Homolog 2, is a mitogen-responsive phosphoprotein that is homologous to the Disabled protein found in fruit flies. It is also referred to as DOC2 or FLJ26626. DAB 2 plays a crucial role in signal transduction pathways, specifically in the regulation of cell growth and survival. It is often implicated in the development and progression of cancer, as well as other pathological conditions. The function of Disabled proteins in vivo is still unknown, but they are believed to play a role in the regulation of growth factor signaling. DAB 2 is a promising target for therapeutic intervention in cancer and other diseases.
Source	Rabbit
Specificity	The DAB2 Antibody is designed to identify total DAB2 levels within the body. It is capable of detecting natural levels of DAB2 within the system.
Species Reactivity	Human;Mouse
Antigen	DAB2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human DAB2.
MW	105 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we undertook peptide affinity chromatography to purify the antiserum to its highest degree.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to a year. It is important to avoid exposing the product to repeated cycles of freezing and thawing as this can affect its stability and efficacy. Be sure to handle the product with care in order to preserve its integrity and effectiveness.
Storage buffer	This product contains Rabbit IgG in a solution consisting of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20°C and it will remain stable for up to 12 months from the date of receipt.
Target
Background	Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor.
Tissue specificity	Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).
Posttranslational modification	Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity).
Celluar localization	Cytosol;Extracellular region or secreted;Lysosome;Nucleus;Plasma Membrane;
UniPort	P98082