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Rabbit Anti-eIF4G Polyclonal Antibody#abs137241

Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis eIF4G using HeLa whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs137241-100ug	1-2 Weeks	301.0
abs137241-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs137241
Other names	EIF4G1, also known as eIF-4-gamma 1 or eukaryotic translation initiation factor 4 gamma 1, is a protein encoded by the DKFZp686A1451 gene. It plays a crucial role in protein synthesis by serving as a component of the eIF4F complex. This complex facilitates the binding of mRNA to the ribosome, leading to the initiation of translation. EIF4G1 interacts with other initiation factors and serves as a scaffolding protein, aiding in the assembly of the translation initiation complex. It is essential for the regulation of gene expression and protein synthesis in eukaryotic cells. EIF4G1 is also known to be involved in various cellular processes, including cell growth, differentiation, and apoptosis. Its dysregulation has been associated with several human diseases, including cancer. Overall, EIF4G1 is a crucial protein in the control of translation initiation and plays a vital role in cellular homeostasis.
Source	Rabbit
Specificity	The eIF4G Antibody is capable of detecting the complete levels of endogenous eIF4G. To produce related content, the information from the original text has been rearranged while preserving its meaning.
Species Reactivity	Human
Antigen	eIF4G
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human eIF4G.
MW	220 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum via peptide affinity chromatography. To obtain a highly similar content, the text can be rearranged as follows: The purification of the antiserum involved the application of SulfoLink™ Coupling Resin in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	The storage recommendation for one year is to store at -20 °C. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The Rabbit IgG is stored in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and has a shelf life of 12 months from the date of receipt. Please note that this content was generated using a language model and may not adhere to the original text structure or wording.
Target
Background	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
Posttranslational modification	Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
Celluar localization	Cytosol;Nucleus;
UniPort	Q04637