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Rabbit Anti-Mnk1 Polyclonal Antibody#abs137240

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Description

Catalog-specification	Delivery time	USD price
abs137240-100ug	1-2 Weeks	301.0
abs137240-50ug	1-2 Weeks	201.0

Overview
catalog	abs137240
Other names	MKNK1，MAP1，MAP/。MKNK1，MAP，。：MAP1、MAP-1、MAP/1、MAPK1、MITOGEN/1、mknk1、MKNK1_HUMAN、MNK 1、Mnk1。
Source	Rabbit
Specificity	The Mnk1 Antibody is designed to specifically detect the endogenous levels of total Mnk1 protein. It is a reliable tool for researchers to study the expression and localization of Mnk1 in various biological samples. By using this antibody, scientists can investigate the role of Mnk1 in different cellular processes and pathways, including cell signaling and protein translation regulation. This antibody is highly sensitive and can provide accurate results in experiments involving Mnk1 detection. The use of this antibody enables researchers to gain valuable insights into the function and regulation of Mnk1 in normal and pathological conditions.
Species Reactivity	Human
Antigen	MNK1
Application	Here are a few examples of how the text can be rearranged: - You can use a dilution range of 1:1000 to 1:3000 if you plan on performing a Western blot. If you're interested in doing an immunofluorescence or immunocytochemistry experiment, the recommended dilution range is 1:100 to 1:500. On the other hand, if you're doing an ELISA with a peptide, you should dilute your antibody at 1:20000 to 1:40000. - For Western blotting, we suggest diluting your antibody to a concentration of 1:1000 to 1:3000, while for immunofluorescence or immunocytochemistry applications, a dilution of 1:100 to 1:500 is appropriate. If you're going to perform an ELISA with a peptide, it's best to dilute your antibody range between 1:20000 to 1:40000. - Depending on the experiment you want to conduct, you'll need to dilute your antibody at different concentrations. To perform Western blotting, we suggest using a dilution range of 1:1000 to 1:3000. If you're doing immunofluorescence or immunocytochemistry, you should dilute your antibody to 1:100 to 1:500. Finally, if you're planning on running an ELISA with a peptide, you'll need to use an antibody dilution range of 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human Mnk1.
MW	83 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To achieve this, the resin was coupled to a peptide sequence that specifically binds to the desired antibodies within the antiserum. This process allowed for the selective purification of the antibodies of interest, leading to a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C，/。
Storage buffer	The storage conditions for rabbit IgG are as follows: it should be kept in phosphate-buffered saline at a pH of 7.4, with a concentration of 150mM NaCl. Additionally, it should contain 0.02% sodium azide and 50% glycerol. The recommended storage temperature is -20 °C. It is important to note that the stability of the IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Tissue specificity	Ubiquitous.
Posttranslational modification	Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9BUB5