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Rabbit Anti-IGFBP2 Polyclonal Antibody#abs137242

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Description

Catalog-specification	Delivery time	USD price
abs137242-50ug	1-2 Weeks	201.0
abs137242-100ug	1-2 Weeks	301.0

Overview
catalog	abs137242
Other names	IGF binding protein 2, also known as IGFBP-2 or IGF BP53, is a 36kDa protein involved in the regulation of insulin-like growth factors (IGFs). It functions as a binding partner for IGFs, specifically IGF-1 and IGF-2, thereby modulating their activity. IGFBP-2 is produced by various cell types and is found in the bloodstream as well as in tissues. It plays a crucial role in controlling the bioavailability of IGFs, extending their half-life and protecting them from degradation. By binding to IGFs, IGFBP-2 regulates their distribution, transport, and interaction with cell surface receptors. This protein is also implicated in cell growth, differentiation, and survival, making it an important regulator of cellular processes. It has been studied in the context of cancer, development, and metabolic disorders. Understanding the role of IGFBP-2 provides insights into the intricate mechanisms that govern the IGF signaling pathway and its implications for health and disease.
Source	Rabbit
Specificity	The IGFBP2 Antibody has the ability to identify total IGFBP2 levels found naturally within the body. In other words, it has the capacity to locate the full range of IGFBP2 present in the body.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	IGFBP2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IGFBP2.
MW	35 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. Let me generate a highly similar content by rearranging the original information: Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the item is stored at a temperature of -20 °C for a period of one year, taking care to prevent any repeated freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is -20 °C in phosphate buffered saline with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the IgG at this temperature for up to 12 months starting from the date of receipt.
Target
Background	Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Posttranslational modification	O-glycosylated.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P18065