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Rabbit Anti-GAP43 Polyclonal Antibody#abs137243

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Description

Catalog-specification	Delivery time	USD price
abs137243-100ug	1-2 Weeks	301.0
abs137243-50ug	1-2 Weeks	201.0

Overview
catalog	abs137243
Other names	GAP 43, also known as growth-associated protein 43 or neuromodulin, is an important axonal membrane protein. It is also referred to as B 50, PP46, or protein F1. This protein plays a crucial role in neuronal growth and development. Its function involves calmodulin binding and it is associated with nerve growth related peptide. Commonly found in neural tissues, GAP 43 is involved in modulating neuronal plasticity. It is highly expressed in growth cones, which are specialized structures at the tips of developing axons. Furthermore, it has been identified as a neural phosphoprotein B-50. Research on GAP 43 has highlighted its significance in axonal regeneration and synaptic plasticity, particularly during periods of neuronal development and repair. Its expression is tightly regulated and plays a crucial role in signaling pathways and cytoskeleton dynamics. In conclusion, GAP 43 is a vital protein involved in neuronal growth and plasticity. Its multiple aliases reflect its diverse functions and importance in neurobiology.
Source	Rabbit
Specificity	GAP43 Antibody is designed to recognize and measure the natural levels of total GAP43 protein in the body. This antibody can effectively detect the endogenous levels of GAP43, allowing researchers to study its expression and function. By targeting the endogenous GAP43 protein, this antibody provides valuable insights into various physiological and pathological processes where GAP43 is involved. Its detection capability enables scientists to investigate the role of GAP43 in development, plasticity, and regeneration of the nervous system, as well as its potential implications in neurodegenerative disorders. Overall, the GAP43 Antibody is a crucial tool in the study of GAP43 protein and its biological functions.
Species Reactivity	Human;Mouse;Rat
Antigen	GAP43
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human GAP43.
MW	43 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, a peptide affinity chromatography technique was utilized to purify the antiserum. This procedure allowed for the isolation of a highly purified form of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity and quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this may compromise its integrity. Therefore, proper storage and handling of the product is crucial to maintain its effectiveness and reliability.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this product at -20 °C for maximum stability. It is stable for at least 12 months from the date of receipt.
Target
Background	This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Posttranslational modification	Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
Celluar localization	Plasma Membrane;
UniPort	P17677