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Rabbit Anti-ELL2 Polyclonal Antibody#abs132634

Please note that the price mentioned in the previous message is for your reference only. For detailed pricing information, we advise you to get in touch with our sales representative, Vecent. Thank you. Western blot analysis of ELL2 expression in 293 cell lysate,The lane on the left is treated...

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Description

Catalog-specification	Delivery time	USD price
abs132634-100ug	1-2 Weeks	301.0
abs132634-50ug	1-2 Weeks	201.0

Overview
catalog	abs132634
Description	One possible rearrangement of the content could be: Suppression of transient pausing by RNA polymerase II at multiple sites along the DNA can be achieved by an elongation factor. This factor plays a crucial role in increasing the catalytic rate of transcription by the polymerase.
Other names	ELL2, also known as elongation factor for RNA polymerase II 2, is an important protein involved in RNA polymerase II elongation. This protein plays a crucial role in the transcriptional elongation of genes, which is essential for proper gene expression and regulation. ELL2 is a highly conserved protein found in many species, including humans. It works by interacting with RNA polymerase II to enhance its processivity and promote efficient transcription elongation. ELL2 is an essential factor in the regulation of gene expression, and its dysregulation has been linked to various diseases, including cancer. Overall, ELL2 is an important protein involved in the maintenance of proper gene expression and regulation, and its function is critical for normal cellular processes.
Source	Rabbit
Specificity	Endogenous levels of total ELL2 can be detected by using the ELL2 antibody. This immunological tool is highly specific and reliable in determining the presence of this protein in biological samples. By utilizing the ELL2 antibody, researchers can examine the expression and function of ELL2 in various biological pathways and processes. Therefore, this antibody is a valuable tool for investigating the role of ELL2 in physiological and pathological conditions.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	ELL2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	72 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, keep the item at a temperature of -20 °C for a period of one year. It is important to prevent the item from going through multiple freeze/thaw cycles, as this can have a negative impact on its effectiveness.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
Posttranslational modification	Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination.
Celluar localization	Nucleus;
UniPort	O00472