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Rabbit Anti-RELN Polyclonal Antibody#abs139363

Description

Catalog-specification	Delivery time	USD price
abs139363-100ug	1-2 Weeks	301.0
abs139363-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For the detailed pricing information, kindly reach out to our seller Vecent. It is important to keep in mind that the content generated through language models may differ significantly from the original text information. Therefore, kindly avoid relying solely on ChapGPT generated content and instead aim to generate highly similar content through appropriate rearrangement of the original text.

Overview
catalog	abs139363
Other names	LIS2 (also known as PRO1598) is a gene that encodes the Reeler protein, commonly referred to as Reelin. Reelin is produced by the RELN gene and is found in humans under the name RELN_HUMAN or RL. To generate content that is highly similar to the original text, the information provided about the gene and protein can be rearranged and summarized as follows: The LIS2 gene, also known as PRO1598, is responsible for encoding the Reeler protein called Reelin. Reelin is produced by the RELN gene and is commonly referred to as RELN_HUMAN or RL in humans.
Source	Rabbit
Specificity	The RELN Antibody has the ability to identify total RELN levels that occur naturally within an organism. To create similar content using the information from the original text, the wording could be adjusted to state that the RELN Antibody is capable of detecting the endogenous amount of total RELN.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Dog;Horse
Antigen	RELN
Application	The recommended dilutions for Western Blotting (WB) range from 1:1000 to 1:3000. Immunohistochemistry (IHC) should be performed at a dilution of 1:200. For ELISA with peptide detection, the suggested dilutions are between 1:20000 and 1:40000. It is important to follow these guidelines to achieve accurate and reliable results. Please note that this information is specific to the mentioned assays and dilutions may vary for other techniques or targets.
Immunogen	A synthesized peptide derived from human RELN.
MW	388kDa
Properties
Concentration	1mg/ml
purification	To purify the antiserum, the SulfoLink™ Coupling Resin was employed in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its integrity, store the item at a temperature of -20 °C for a duration of one year. It is important to prevent the item from undergoing multiple freeze/thaw cycles.
Storage buffer	The storage solution for Rabbit IgG is phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and remains stable for 12 months from the date of receipt.
Target
Background	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).
Tissue specificity	Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P78509