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Rabbit Anti-JAM2 Polyclonal Antibody#abs132929

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis of JAM2 expression in ?HUVEC cell lysate,The lane on the left is treated with the antigen-specific peptide....

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Description

Catalog-specification	Delivery time	USD price
abs132929-100ug	1-2 Weeks	301.0
abs132929-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent.

Overview
catalog	abs132929
Description	The processes of lymphocyte homing to secondary lymphoid organs may be influenced by several factors.
Other names	The protein coded by the C21orf43 gene is known as Junction Adhesion Molecule 2 or JAM-2. It is also referred to as CD322 or CD322 antigen. JAM-2 is an integral membrane protein that plays a crucial role in the formation of tight junctions between endothelial cells. JAM-2 is expressed on the surface of leukocytes, platelets, and vascular endothelial cells. It is involved in leukocyte trafficking, cell adhesion, and platelet activation. JAM-2 belongs to the family of Junctional Adhesion Molecules (JAMs), which also includes JAM-A and JAM-C. JAM-2 is composed of two extracellular immunoglobulin-like domains, a single transmembrane segment, and a short cytoplasmic tail. JAM-2 mediates interactions between neighboring cells through homophilic binding. Junctional Adhesion Molecule B (JAM-B) is another name for JAM-2. It is also referred to as vascular endothelial JAM, VE-JAM, VE-Junction Associated Molecule, or PRO 245. JAM-B is expressed on the surface of endothelial and epithelial cells and plays a crucial role in the formation of tight junctions between cells. Overall, JAM-2 and JAM-B are key players in maintaining the integrity of tight junctions and regulating leukocyte migration through the endothelium. Dysfunction of these proteins has been implicated in various immune and cardiovascular diseases.
Source	Rabbit
Specificity	The JAM2 antibody is able to recognize total JAM2 that is present in the body naturally. This indicates that the antibody is capable of detecting JAM2 levels without the need for introduction of external factors or modifications. To put it in another way, the JAM2 antibody is effective in detecting the endogenous levels of total JAM2.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	JAM2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	33 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
Tissue specificity	Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
Celluar localization	Plasma Membrane;
UniPort	P57087