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Rabbit Anti-NLGN3 Polyclonal Antibody#abs139212

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Description

Catalog-specification	Delivery time	USD price
abs139212-100ug	1-2 Weeks	301.0
abs139212-50ug	1-2 Weeks	201.0

Overview
catalog	abs139212
Other names	HNL3, also known as gliotactin homolog and Neuroligin-3, is a protein that plays an important role in synaptic function in the brain. It is coded by the NLGN3 gene in humans. NLGN3_HUMAN is the designated name for this protein in scientific literature. This protein is highly expressed in the nervous system and is involved in the formation and maintenance of synapses between neurons. Its function is associated with the formation of inhibitory synapses, which play a critical role in regulating the excitability of neuronal circuits. Dysregulation of HNL3 has been associated with various neurological disorders, including autism spectrum disorders. Further research is needed to fully understand the complex functions of HNL3 and its role in neurological diseases. However, its importance in synaptic function and regulation makes it an important target for future therapeutic interventions in neurological disorders. The study of this protein has the potential to unlock important new discoveries and improve our understanding of the brain and its functions.
Source	Rabbit
Specificity	The total NLGN3 levels can be effectively detected by the NLGN3 Antibody, targeting the endogenous proteins. In order to ensure accurate measurement, it is essential to use a highly specific antibody that can recognize and bind to the total NLGN3 present in the sample. This antibody offers a valuable tool for researchers to study the expression and function of NLGN3 in various biological systems.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	NLGN3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NLGN3.
MW	94 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is advisable to avoid multiple cycles of freeze/thaw, as this may have an adverse effect on the product's efficacy.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the product is guaranteed for 12 months from the date of receipt.
Target
Background	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).
Tissue specificity	Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
Celluar localization	Plasma Membrane;
UniPort	Q9NZ94