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Rabbit Anti-Defensin Beta2 Polyclonal Antibody#abs138051

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Description

Catalog-specification	Delivery time	USD price
abs138051-100ug	1-2 Weeks	301.0
abs138051-50ug	1-2 Weeks	201.0

Overview
catalog	abs138051
Other names	Beta defensin 2, also known as BD-2, is a peptide that belongs to the defensin family. It is expressed in epithelia of various human tissues, including the skin and respiratory and gastrointestinal tracts. Beta defensin 2 plays a significant role in the innate immune response by acting as an antimicrobial agent against a wide range of microorganisms. It is capable of killing bacteria, fungi, and viruses by disrupting their cell membranes. The gene for beta defensin 2, DEFB2, maps to chromosome 8p23.1 and is comprised of four exons. Alternative splicing of the DEFB2 gene produces multiple transcript variants, including DEFB4A and DEFB4B. These variants are present on chromosome 8p23.1 in the form of two functional genes and one pseudogene. Researchers believe that beta defensin 2 is a promising therapeutic agent due to its potent antimicrobial activity and lack of side effects.
Source	Rabbit
Specificity	The Defensin β2 Antibody is capable of detecting the total amount of Defensin β2 that is naturally present in an organism. This means that it is possible to accurately assess the levels of Defensin β2 in biological samples using this particular antibody.
Species Reactivity	Human
Antigen	Defensin β2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	Defensin β2, an essential component of the human immune system, can be utilized to synthesize a peptide with remarkable similarity. By harnessing the very building blocks found within human Defensin β2, a synthesized peptide can be crafted, yielding a product that closely mirrors the original source material. This process ensures that the resulting peptide carries the innate defensive properties of Defensin β2 while maintaining a high degree of similarity to its human-derived counterpart. Thus, through thoughtful rearrangement and strategic utilization of original text information, a highly similar peptide can be synthesized from human Defensin β2.
MW	7 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography. The resulting content will closely resemble the original information, but with a slightly different structure and phrasing.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it is recommended to store it at -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze-thaw cycles, as this can adversely affect its properties. Therefore, it is essential to follow the storage instructions to ensure that the product remains stable and effective for its intended use.
Storage buffer	This product is a Rabbit IgG in a solution of phosphate buffered saline at a pH of 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and is stable for up to 12 months from your date of receipt.
Target
Background	Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).
Tissue specificity	Expressed in the skin and respiratory tract.
Celluar localization	Extracellular region or secreted;Golgi apparatus;
UniPort	O15263