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Rabbit Anti-FEV Polyclonal Antibody#abs134977

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Description

Catalog-specification	Delivery time	USD price
abs134977-100ug	1-2 Weeks	301.0
abs134977-50ug	1-2 Weeks	201.0

Overview
catalog	abs134977
Other names	FEV is a transcription factor belonging to the ETS oncogene family, known for its crucial role in regulating gene expression. Also referred to as PC12 ETS domain-containing transcription factor 1, Pet-1 or Fifth Ewing variant protein, FEV is involved in a variety of biological processes including cell growth, development, differentiation and oncogenesis. The protein is commonly found in high levels in the brain and is thought to be a crucial determinant of serotonergic neuron differentiation, making it a potential therapeutic target for a range of neurological disorders. Furthermore, the HSRNAFEV gene has been identified as a potential regulator of FEV expression, adding to the complexity of the gene regulation system. Overall, the multifaceted role of FEV in controlling various cellular processes highlights its importance as a key transcriptional regulator.
Source	Rabbit
Specificity	The total FEV can be detected with the FEV Antibody, which is capable of detecting the endogenous levels of FEV.
Species Reactivity	Human
Antigen	FEV
Application	The recommended dilution for Western blot is between 1:500 to 1:1000, while for immunofluorescence or immunocytochemistry it is 1:100 to 1:500. For ELISA using peptide, the suggested dilution is between 1:20000 to 1:40000. These dilutions should be followed for optimal results and to ensure that the antibody is used efficiently.
Immunogen	A synthesized peptide.
MW	25 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resultant product was highly pure and effective.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain product quality, it is recommended to store at a temperature of -20 °C for one year. It is important to prevent repeated freeze/thaw cycles.
Storage buffer	The recommended storage condition for Rabbit IgG is at -20 °C. It is supplied in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This formulation ensures stability for a period of 12 months from the date of receipt.
Target
Background	Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
Tissue specificity	In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.
Celluar localization	Nucleus;
UniPort	Q99581

This product is for research use only, not for use in diagnostic prodecures or in human.

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