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Rabbit Anti-GLRB Polyclonal Antibody#abs141167

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts from A549 cells and K562 cells, using GLRB antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs141167-100ug	1-2 Weeks	301.0
abs141167-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs141167
Other names	The beta subunit of the glycine receptor, also known as the 58 kDa subunit, plays a crucial role in receptor function. It is encoded by the genes OTTHUMP00000220896 and OTTHUMP00000220897. This subunit is vital for the proper functioning of the glycine receptor and is involved in mediating inhibitory neurotransmission in the central nervous system. Its rearrangement and interaction with other subunits contribute to the diverse properties of the glycine receptor. Understanding the structure and function of the glycine receptor beta subunit is important in unraveling the mechanisms underlying inhibitory neurotransmission and could potentially lead to the development of novel therapies for neurological disorders.
Source	Rabbit
Specificity	The GLRB Antibody is capable of detecting the overall levels of endogenous GLRB in an organism. This information is relevant in understanding the biological processes and maintaining a comprehensive study of the GLRB protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	GLRB
Application	WB 1:500~1:1000、IF/ICC 1:100-1:500ELISA(peptide) 1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	56 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. It ensured that any impurities were removed, leaving behind a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the stability of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this may affect its quality and efficacy. Taking these precautions will help to maintain the integrity of the product and ensure that it remains safe and effective for use. If you have any concerns or questions about the storage or use of the product, please consult with a healthcare professional or the manufacturer for guidance.
Storage buffer	The solution contains Rabbit IgG in phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This solution should be stored at -20 °C. It is stable for a period of 12 months starting from the date of receipt.
Target
Background	Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Celluar localization	Plasma Membrane;
UniPort	P48167