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Rabbit Anti-ABI2 Polyclonal Antibody#abs137547

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Description

Catalog-specification	Delivery time	USD price
abs137547-100ug	1-2 Weeks	301.0
abs137547-50ug	1-2 Weeks	201.0

Overview
catalog	abs137547
Other names	Abelson interactor 2, also known as ABI2 or AIP 1, is a protein that interacts with the Abl tyrosine kinase and plays a role in actin cytoskeleton regulation, cell migration, and signaling pathways. It is also involved in the assembly and disassembly of focal adhesions, structures that link the extracellular matrix to the cell cytoskeleton. ABI2 contains an SH3 domain, which mediates protein-protein interactions, and a proline-rich region that binds to proteins with SH3 domains. There are multiple splice variants of ABI2, including ABI2B, and it is expressed in various tissues, including the brain, heart, and liver. Dysfunction of ABI2 has been associated with cancer and neurodegenerative diseases. Overall, ABI2 is an important player in cellular processes and signaling pathways that affect cell behavior and health.
Source	Rabbit
Specificity	The ABI2 Antibody is capable of detecting the total amount of endogenous ABI2 protein present in the biological sample. This means that the antibody can specifically identify and measure the levels of ABI2 protein that are naturally occurring in the sample. It is important to note that the antibody detects the total amount of ABI2, rather than differentiating between various isoforms or phosphorylated forms of the protein. Through this antibody, researchers can determine the expression and activity of ABI2 in different tissues and cells, which are crucial for understanding its role in various physiological processes.
Species Reactivity	Human
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	ABI2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ABI2.
MW	80 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. Similar content can be created by rephrasing the original text while maintaining its meaning and context.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the item stored at a temperature of -20 °C for up to a year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this could potentially impact its quality.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Posttranslational modification	Is a substrate for ABL1.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	Q9NYB9