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Rabbit Anti-Sall4 Polyclonal Antibody#abs137234

Description

Catalog-specification	Delivery time	USD price
abs137234-100ug	1-2 Weeks	301.0
abs137234-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137234
Other names	Sall4, also known as Sal like 4 or Zinc finger protein SALL4, is a transcription factor that plays a crucial role in embryonic development and stem cell maintenance. It is encoded by the C330011P20Rik gene and its expression is regulated by the Spalt family of transcription factors. Sall4 is highly conserved across species, including humans, and is involved in a wide range of cellular processes, such as cell proliferation, differentiation, and apoptosis. It has also been implicated in tumorigenesis and is considered a potential therapeutic target for cancer treatment. Other names for Sall4 include HSAL4, Tex20, Zinc finger protein 797, and ZNF797. The protein structure of Sall4 contains four C2H2 zinc fingers and two nuclear localization signals, which play a critical role in its function as a transcription factor.
Source	Rabbit
Specificity	The detection of total Sall4 is accomplished by the Sall4 antibody, which is capable of identifying the endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	Sall4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Sall4.
MW	140 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. To ensure the highest degree of similarity, the original text information was kept intact and rearranged for this statement.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimum storage conditions, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repetitive freeze/thaw cycles as this may impact its integrity and effectiveness.
Storage buffer	The storage conditions for Rabbit IgG in Phosphate Buffered Saline are as follows: it should be stored at -20 °C and maintained in a solution containing 150mM NaCl, 50% glycerol, 0.02% sodium azide, and a pH of 7.4. It is important to note that this product remains stable for a period of 12 months starting from the date it was received.
Target
Background	Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Tissue specificity	Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).
Posttranslational modification	Isoform SALL4B exists primarily as a ubiquitinated form.Sumoylation with both SUMO1 and SUMO2 regulates the stability, subcellular localization, transcriptional activity, and may reduce interaction with POU5F1/OCT4.
Celluar localization	Nucleus;
UniPort	Q9UJQ4