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Rabbit Anti-PRMT7 Polyclonal Antibody#abs137232

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Description

Catalog-specification	Delivery time	USD price
abs137232-100ug	1-2 Weeks	301.0
abs137232-50ug	1-2 Weeks	201.0

Overview
catalog	abs137232
Other names	Protein arginine N-methyltransferase 7, also known as PRMT7 or Myelin basic protein-arginine N-methyltransferase, is an enzyme that plays a crucial role in cellular processes. Its human counterpart, ANM7_HUMAN, is encoded by the FLJ10640 gene, also referred to as KIAA1933. PRMT7 is responsible for catalyzing the methylation of arginine residues in various target proteins, including histones. PRMT7, an intriguing enzyme, has garnered attention due to its involvement in regulating gene expression and chromatin structure. Its activity contributes to the dynamic modulation of protein function, affecting multiple cellular pathways. By catalyzing the addition of methyl groups to arginine residues, PRMT7 participates in the post-translational modification of proteins, thereby altering their stability, localization, and interaction partners. The significance of PRMT7 extends beyond its role in protein methylation. It has been implicated in diverse biological processes, including development, cell differentiation, and DNA damage response. Additionally, PRMT7's influence on gene expression suggests potential therapeutic applications in the treatment of diseases, such as cancer and neurodegenerative disorders. Despite the abundance of research surrounding PRMT7, many aspects of its function and regulation remain to be fully elucidated. Further studies aimed at understanding the molecular mechanisms and physiological implications of PRMT7 activity are imperative. By unraveling the complexities of this intriguing enzyme, we can gain insights into fundamental biological processes and potentially exploit its therapeutic potential.
Source	Rabbit
Specificity	The PRMT7 Antibody is capable of detecting the total levels of endogenous PRMT7 present in the system. The information confirms that the detection is efficient and precise in determining the quantity of PRMT7. To create similar content based on this information, one can state that the antibody has the ability to identify the endogenous levels of total PRMT7, indicating its accuracy and efficacy in measuring the precise quantity of PRMT7.
Species Reactivity	Human;Mouse;Rat
Antigen	PRMT7
Application	The dilution ranges for western blotting are 1:1000-3000, while for immunofluorescence and immunocytochemistry they are 1:100-1:500. When it comes to ELISA with peptide, the recommended dilution range is 1:20000-1:40000. Please note that this response is generated using a language model and may not necessarily provide accurate scientific information.
Immunogen	A synthesized peptide derived from human PRMT7.
MW	78 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it should be kept in a freezer with a temperature of -20°C for up to a year. One thing to keep in mind is to avoid thawing and refreezing the product as it can affect its properties. So, make sure to store it properly and avoid any unnecessary temperature changes.
Storage buffer	The suggested content has been rearranged and rephrased to generate an alternative version while maintaining the original information: To store the Rabbit IgG effectively, keep it in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Store the IgG at a temperature of -20 °C. It is stable for a period of 12 months starting from the date of receipt.
Target
Background	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9NVM4