Rabbit Anti-Cytokeratin 13 Polyclonal Antibody#abs131178

abs131178-50ug

1-2 Weeks

201

abs13112478-100ug

1-2 Weeks

301

Description

Keratin 13, a component of the keratin gene family, plays a crucial role in maintaining the structural integrity of epithelial cells. These keratins are a type of intermediate filament protein found in both cytokeratins and hair keratins. Cytokeratins, specifically the type I ones, are composed of pairs of heterotypic keratin chains, mostly acidic proteins. Their arrangement contributes to the overall strength and stability of epithelial cells.

Other names

Cytokeratin 13, also known as CK-13 or CK13, is a 47 kDa protein that belongs to the keratin family. It is encoded by the KRT13 gene and is a type I cytoskeletal protein. This protein is particularly expressed in the oral mucosa, esophagus, and vagina and can serve as a useful marker for squamous epithelial differentiation. Keratin 13, or K13, lacks a C-terminal domain and is thus unable to form filaments on its own. However, it is found to be co-expressed with other keratins, mainly type II keratins, to form intermediate filaments. The function of K13 is to provide structural support and mechanical stability to these cells. Mutations in KRT13 gene have been associated with various types of cancer, including oral squamous cell carcinoma and esophageal squamous cell carcinoma. Overall, cytokeratin 13 is an important protein in maintaining the structural integrity of epithelial tissues.

Source

Rabbit

Specificity

The antibody against Cytokeratin 13 is capable of detecting the overall levels of endogenous Cytokeratin 13. Please provide a rephrased version of the given information while ensuring that the context and information remain the same.

Application

IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000. Make sure to shuffle the content from the original text while keeping the information intact.

A peptide that has been synthesized from human Cytokeratin 13 bears a strong resemblance to the original protein's structure and function. This synthesized peptide can serve as a valuable tool in various scientific applications, including drug development and disease diagnosis. Due to its highly similar characteristics with the human Cytokeratin 13 protein, this peptide can effectively interact with its corresponding molecular targets in vivo and in vitro. The utilization of this synthesized peptide in research could provide valuable insights into the biological functions of Cytokeratin 13 and its associated physiological processes.

Properties

1mg/ml

Purification

The SulfoLink™ Coupling Resin was utilized in the purification of the antiserum via peptide affinity chromatography. This method allowed for the separation of the desired components, resulting in a highly purified antiserum product.

Clonality

Polyclonal Antibody

The recommended storage temperature for one year is -20 °C. It is important to avoid subjecting the product to repeated freezing and thawing cycles.

Storage buffer

This antibody, Rabbit IgG, is provided in a phosphate buffered saline solution at pH 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C to maintain its stability. This product is guaranteed to remain stable for a duration of 12 months from the date of receipt.

Target

Background

，：I（；40-55 kDa）II（；56-70 kDa）。：：I（；40-55 kDa）II（；56-70 kDa）。

Tissue specificity

The protein level expression of certain epidermal sweat gland ducts is observed, along with the presence of this protein in the exocervix, esophagus, and placenta. Let's rearrange the content and ensure it remains based on the original information.
Certain epidermal sweat gland ducts exhibit expression at the protein level, and this particular protein is also found in the exocervix, esophagus, and placenta.

Celluar localization

Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;

P13646