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Rabbit Anti-IL-13Ralpha1 Polyclonal Antibody#abs140449

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Description

Catalog-specification	Delivery time	USD price
abs140449-100ug	1-2 Weeks	301.0
abs140449-50ug	1-2 Weeks	201.0

Overview
catalog	abs140449
Other names	IL-13 receptor alpha 1, also known as IL-13Rα1 or CD213a1, is a protein encoded by the IL13RA1 gene. It is a receptor subunit involved in the binding of interleukin 13 (IL-13), a cytokine known for its role in allergic and inflammatory responses. IL-13Rα1 is also referred to as cancer/testis antigen 19 (CT19) or NR4, and it plays a crucial role in various biological processes. IL-13Rα1 is a target for therapeutic interventions in several diseases, including cancer. Its expression is typically limited to certain tissues and cell types, making it a potential biomarker for diagnosis and treatment strategies. The IL13RA1 gene encodes the IL-13 receptor alpha 1 chain, which forms a complex with other subunits to create functional heterodimeric receptors for IL-13 signaling. Understanding the biological functions and molecular mechanisms of IL-13Rα1 can provide valuable insights into disease pathogenesis and guide the development of targeted therapies. Further research is needed to explore its potential as a therapeutic target and to elucidate its role in various physiological and pathological conditions.
Source	Rabbit
Specificity	The detection of total IL-13Ralpha1 at endogenous levels can be achieved using the IL-13Ralpha1 Antibody. Consider rearranging the content to generate a highly similar version while ensuring that the information remains consistent.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	IL-13Ralpha1
Application	The dilutions for WB, IHC, IF/ICC, and ELISA (peptide) are as follows: WB at 1:1000, IHC at 1:200, IF/ICC at 1:100-1:500, and ELISA (peptide) at 1:20000-1:40000.
Immunogen	The human IL-13Ralpha1 can be used to develop a synthesized peptide with high similarity. By rearranging the sequence of this peptide, we can create a content that is based on the original text information. It is important to note that the content generated should be distinct from the way in which ChapGPT generates content.
MW	49kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Tissue specificity	Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Celluar localization	Plasma Membrane;
UniPort	P78552