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Rabbit Anti-MARK Polyclonal Antibody#abs133759

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Description

Catalog-specification	Delivery time	USD price
abs133759-100ug	1-2 Weeks	301.0
abs133759-50ug	1-2 Weeks	201.0

Overview
catalog	abs133759
Other names	This is a list of various names that describe the same group of proteins known as MAP/microtubule affinity-regulating kinases (MARKs). There are four different isoforms of these kinases, each with unique names and similar functions. The four isoforms of MAP/microtubule affinity-regulating kinases are known as MARK1, MARK2, MARK3, and MARK4. They are all serine/threonine protein kinases that are involved in regulating the affinity of microtubules for various proteins. MARK1 is also commonly referred to as EMK-1, ELKL motif kinase 1, or simply MARK. MARK2 may also be referred to as EMK1, ELKL motif kinase 2, or PAR1 homolog. MARK3 is sometimes called Ser/Thr protein kinase PAR-1 or Par1a, while MARK4 may also be referred to as MARKL1 or MARK4S. Other names that have been used to describe these proteins include MAP/microtubule affinity regulating kinase 1-4, Serine/threonine protein kinase MARK1-4, Cdc25C-associated protein kinase 1, ETK1, KP78, Protein kinase STK10, and Putative protein product of Nbla00650. While these names may seem confusing, it is important to remember that they all refer to the same group of proteins with similar functions. Understanding the different names and uses of these proteins can help researchers better understand their roles in cellular processes and disease.
Source	Rabbit
Specificity	The endogenous levels of total MARK can be detected using the MARK Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	MARK
Application	WB 1:500~1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	89 KD
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Tissue specificity	Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Posttranslational modification	Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q9P0L2/Q7KZI7/P27448/Q96L34