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Rabbit Anti-THOC5 Polyclonal Antibody#abs137903

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Description

Catalog-specification	Delivery time	USD price
abs137903-100ug	1-2 Weeks	301.0
abs137903-50ug	1-2 Weeks	201.0

Overview
catalog	abs137903
Other names	Chromosome 22 open reading frame 19, also known as C22orf19, is a protein of interest that interacts with Fms, a signaling protein. It is also known as Fmip or fSAP79. This protein, encoded by the gene KIAA0983 or LOC400922, is involved in spliceosome assembly and is a component of the functional spliceosome-associated complex. It is alternatively referred to as hTREX90 or PK1.3 due to its association with the NF2/meningioma region protein pK1.3. Another name for this protein is Placental protein 39.2 or PP39.2. Its role in the THO complex, specifically as THO complex subunit 5 or THOC5, suggests its involvement in RNA metabolism and transport. THOC5_HUMAN is the designated gene symbol for this protein in humans.
Source	Rabbit
Specificity	The THOC5 Antibody is designed to identify the total amount of THOC5 present in cells at a natural level. Its purpose is to detect and determine the quantities of endogenous THOC5 within samples.
Species Reactivity	Human
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	THOC5
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human THOC5.
MW	79 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain quality, keep the item at a temperature of -20 °C for a period of one year. It is advisable to avoid frequent freezing and thawing cycles.
Storage buffer	The storage conditions for Rabbit IgG are as follows: It should be stored at -20 °C in a solution containing 150mM NaCl, phosphate buffered saline with a pH of 7.4, 0.02% sodium azide, and 50% glycerol. This product is stable for a period of 12 months from the date of receipt.
Target
Background	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.
Tissue specificity	Ubiquitously expressed.
Posttranslational modification	Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding.
Celluar localization	Nucleus;
UniPort	Q13769