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Rabbit Anti-TSG101 Polyclonal Antibody#abs137904

Description

Catalog-specification	Delivery time	USD price
abs137904-100ug	1-2 Weeks	301.0
abs137904-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137904
Other names	The TSG101 protein, also known as tumor susceptibility gene 101 protein, is a subunit of the ESCRT I complex. This protein is encoded by the TSG101 gene and is involved in various cellular processes, including the sorting of membrane proteins, the formation of multivesicular bodies, and the budding of viruses. TSG101 has also been implicated in the progression of certain cancers and is considered a tumor susceptibility gene. Additionally, this protein has been shown to interact with several other proteins, including VPS23, which is another subunit of the ESCRT I complex. The precise role of TSG101 in these processes and its potential as a therapeutic target are still areas of active research.
Source	Rabbit
Specificity	The TSG101 Antibody is designed to recognize and measure the levels of total TSG101 protein present in an organism. It specifically detects the endogenous levels of TSG101, providing a valuable tool for research and analysis. The high specificity and sensitivity of this antibody contribute to its effectiveness in studying the expression and function of TSG101. By targeting and detecting the total TSG101 protein, this antibody allows researchers to gain insights into its role in various biological processes.
Species Reactivity	Human;Mouse;Monkey
Predictive reaction species	Rabbit;Dog;Horse
Antigen	TSG101
Application	The recommended dilutions for using antibodies in various applications are as follows: for western blot, a dilution of 1:1000 to 1:3000 is recommended; for immunofluorescence or immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested; and for ELISA with peptide, a dilution range of 1:20000 to 1:40000 is recommended. These dilutions are meant to optimize the performance of the antibodies for their respective applications.
Immunogen	A synthesized peptide derived from human TSG101.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the peptide affinity chromatography technique successfully purified the antiserum. Please proceed to generate a highly analogous context by reorganizing the provided content, while ensuring that the generated content remains faithful to the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal quality, it is recommended to store the product at a temperature of -20°C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this can cause damage to the product. Please ensure that you follow the storage guidelines carefully to ensure the longevity of the product.
Storage buffer	This product is Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. To maintain its stability, it should be stored at a temperature of -20 °C and is said to remain stable for up to 12 months from the date of receipt.
Target
Background	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Tissue specificity	Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
Posttranslational modification	Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.
Celluar localization	Cytoskeleton;Cytosol;Endosome;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q99816