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Rabbit Anti-CCR6 Polyclonal Antibody#abs139727

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Description

Catalog-specification	Delivery time	USD price
abs139727-100ug	1-2 Weeks	301.0
abs139727-50ug	1-2 Weeks	201.0

Overview
catalog	abs139727
Other names	The CC chemokine receptor type 6, also known as CCR6, CD196, or CKR-L3, is a G protein-coupled receptor that plays a vital role in leukocyte migration. This receptor is primarily expressed on T cells, B cells, and dendritic cells, facilitating their movement from the blood to lymphoid and inflamed tissues. CCR6 is also involved in the recruitment of leukocytes to inflamed tissues during an immune response, making it a potential therapeutic target for inflammatory diseases. Additionally, CCR6 has been implicated in the pathogenesis of certain types of cancer, specifically those involving the gastrointestinal tract. Other names for CCR6 include DCR2, GPR29, and STRL22. Its ligands include the chemokine CCL20, which is also known as liver and activation-regulated chemokine (LARC). By understanding the function and regulation of CCR6, researchers can gain insights into the mechanisms underlying immune responses and inflammation.
Source	Rabbit
Specificity	The detection of total CCR6 levels is made possible by the CCR6 Antibody, which effectively identifies the endogenous presence of CCR6. To generate content presenting a distinct approach, we can say that the CCR6 Antibody is capable of determining the overall levels of CCR6 that naturally occur within the system.
Species Reactivity	Human;Mouse
Predictive reaction species	Sheep;Horse;
Antigen	CCR6
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CCR6.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum by performing peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Tissue specificity	Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Celluar localization	Plasma Membrane;
UniPort	P51684