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Rabbit Anti-BCLW Polyclonal Antibody#abs140686

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Description

Catalog-specification	Delivery time	USD price
abs140686-100ug	1-2 Weeks	301.0
abs140686-50ug	1-2 Weeks	201.0

Overview
catalog	abs140686
Other names	The human gene Bcl-2 like 2, also known as BCL W or Bcl2-L-2, encodes a protein that regulates apoptosis. This protein functions similarly to the well-known Bcl-2 protein family, which possesses anti-apoptotic properties. BCL W has been found to be expressed in tissues such as the brain, ovary, and heart. It is thought to be involved in the development and maintenance of these tissues, as well as in the prevention of cell death in response to stress. BCL W interacts with other proteins, including protein phosphatase 1 regulatory subunit 51 (PPP1R51), and its activity can be modulated by its association with these partners. Overall, BCL W plays a critical role in the regulation of apoptosis and cell survival.
Source	Rabbit
Specificity	The BCLW Antibody is designed to identify total BCLW in cells at its natural concentrations.
Species Reactivity	Human;Mouse;Rat
Antigen	BCLW
Application	For Western blotting, the recommended dilution range is 1:500 to 1:1000. When used for Immunofluorescence/Immunocytochemistry, the dilution should be between 1:100 to 1:500. ELISA (peptide) requires a dilution range of 1:20000 to 1:40000. It's essential to follow these dilution guidelines to achieve accurate and reliable results.
Immunogen	A synthesized peptide.
MW	25 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was effectively purified through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep this item in a freezer set at a temperature of -20 °C for a period of one year. It is important to avoid exposing it to multiple freeze/thaw cycles.
Storage buffer	This product contains rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. It also contains 50% glycerol and should be stored at -20 °C. The product remains stable for up to 12 months from the date of receipt.
Target
Background	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Tissue specificity	Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;
UniPort	Q92843