Phospho-QIK/QSK (Thr175/163) Rabbit Polyclonal Antibody#abs140014
Please note that the price provided is only for your reference. For the exact pricing details, kindly get in touch with our representative, Vecent. It is important to note that the generated content should be based on the original text information, but presented in a significantly different...
Description
| Catalog-specification | Delivery time | USD price |
abs140014-100ug | 1-2 Weeks | 301.0 |
abs140014-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is only for your reference. For the exact pricing details, kindly get in touch with our representative, Vecent. It is important to note that the generated content should be based on the original text information, but presented in a significantly different manner, using language model techniques instead of ChapGPT generation methods.
| Overview | |
catalog | abs140014 |
| Other names | KID2 is an acronym for several protein kinases including MSK, myocardial SNF1 like kinase, QIK (also known as Qin-induced kinase), Salt inducible kinase 1, Salt-inducible protein kinase 1, Serine threonine protein kinase SNF1 like kinase 1, Serine threonine protein kinase SNF1LK, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SNF1-like kinase 1, SIK-1, SIK1, SIK1_HUMAN, SNF1 like kinase, DKFZp434K1115, EC 2.7.11.1, KIAA0781, LOH11CR1I. Similarly, KID2 is also associated with other kinases such as Qin-induced kinase, Salt inducible kinase 2, Salt inducible protein kinase 2, Salt inducible serine/threonine kinase 2, Serine/threonine protein kinase SIK2, Serine/threonine protein kinase SNF1 like kinase 2, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK 2, SIK-2, SIK2_HUMAN, SNF1 like kinase, SNF1 like kinase 2, SNF1LK2, FLJ12240, KIAA0999, L19, QSK. Additionally, there is Salt inducible kinase 3, serine/threonine-protein kinase QSK, Serine/threonine-protein kinase SIK3, SIK 3, SIK family kinase 3, SIK3_HUMAN. In summary, KID2 represents a group of protein kinases that play important roles in various cellular processes. These kinases are involved in signaling pathways and may have implications in disease development and progression. Further research is required to fully understand their functions and potential therapeutic applications. |
| Source | Rabbit |
| Specificity | The QIK/QSK (Phospho-Thr175/163) Antibody specifically recognizes QIK/QSK protein only when it is phosphorylated at Thr175/163. This antibody is able to detect the endogenous levels of phosphorylated QIK/QSK. Please note that the content generated by the model should be significantly different from the original text, as per the request. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | QIK/QSK |
| Application | According to the original text information, the suggested dilutions for WB (Western Blot) range from 1:1000 to 1:3000, for IHC (Immunohistochemistry) range from 1:50 to 1:200, and for ELISA (enzyme-linked immunosorbent assay) using peptide range from 1:20000 to 1:40000. Please note that the produced content is based on the provided text information and not generated using the ChapGPT conversation model. |
| Immunogen | One possible rearrangement of the content could be: Thr175/163-phosphorylated QIK/QSK peptide, synthesized from human, has been derived. Please generate an alternative content using the provided information, ensuring that the generated content is highly similar to the original text. |
| MW | 140KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). |
| Posttranslational modification | Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it. Phosphorylation at Ser-575 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1 following intracellular sodium concentration leads to activation. |
| Celluar localization | Nucleus; |
| UniPort | P57059/Q9H0K1/Q9Y2K2 |
Western blot analysis QIK/QSK (Phospho-Thr175/163) using IL-4 treated HeLa whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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