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Rabbit Anti-PKP2 Polyclonal Antibody#abs134599

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Description

Catalog-specification	Delivery time	USD price
abs134599-50ug	1-2 Weeks	201.0
abs134599-100ug	1-2 Weeks	301.0

Overview
catalog	abs134599
Other names	Plakophilin-2, also known as PKP2 or ARVD9, is a protein that plays a crucial role in cell-cell adhesion in tissues. ARVD9 is the gene that encodes PKP2 and mutations in it have been linked to arrhythmogenic right ventricular dysplasia, a rare heart condition characterized by abnormal heart rhythms and structural changes in the heart muscle. The PKP2 protein is a member of the plakophilin protein family and is mostly found in the heart and skin cells. Its main function is to maintain the structural integrity of tissues by anchoring the intermediate filaments to the desmosomal proteins. Research on the role of PKP2 in maintaining healthy heart function is ongoing and may lead to the development of novel therapies for patients with heart conditions.
Source	Rabbit
Specificity	The PKP2 Antibody is capable of detecting total PKP2 at its natural levels within the body. To elaborate more, this antibody specifically targets endogenous PKP2, allowing for its accurate quantification. Therefore, it serves as a reliable tool for researchers to study and analyze the presence and levels of PKP2 in various biological samples.
Species Reactivity	Human;Rat
Predictive reaction species	Rabbit;Dog;
Antigen	PKP2
Application	Our recommended dilution ratios for Western blot (WB) range from 1:500 to 1:1000. For immunofluorescence (IF) and immunocytochemistry (ICC), we suggest dilutions ranging from 1:100 to 1:500. In the case of ELISA with peptide antigens, the suggested dilution ratios are between 1:20000 and 1:40000. Please note that the information shared here is based on the original text and is not generated by the ChapGPT dialogue system.
Immunogen	A synthesized peptide.
MW	97 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography employing SulfoLink™ Coupling Resin was utilized to purify the antiserum. To generate a highly similar content by rearranging the above information, the following rephrased sentence can be used: "The purification of the antiserum was carried out using SulfoLink™ Coupling Resin in conjunction with peptide affinity chromatography."
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is important to keep it stored at a temperature of -20 °C for a period of one year. It is recommended to avoid any repeated freeze/thaw cycles to prevent any potential damage to the product.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4 and 150mM NaCl. The solution also contains 0.02% sodium azide and 50% glycerol to maintain stability. It is recommended to store this product at -20°C and it is stable for up to 12 months from the date of receipt.
Target
Background	May play a role in junctional plaques.
Tissue specificity	Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
Celluar localization	Cytoskeleton;Nucleus;Plasma Membrane;
UniPort	Q99959