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Rabbit Anti-PKP4 Polyclonal Antibody#abs134600

Description

Catalog-specification	Delivery time	USD price
abs134600-100ug	1-2 Weeks	301.0
abs134600-50ug	1-2 Weeks	201.0

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Overview
catalog	abs134600
Other names	Plakophilin-4, also known as Catenin 4 or p0071, is a protein encoded by the FLJ31261 and FLJ42243 genes. It plays a crucial role in cell adhesion and is an important component of desmosomes. Catenin4 is the official symbol for Plakophilin-4, which is abbreviated as PKP4. This protein is involved in mediating cell-cell adhesion by binding to other desmosomal proteins. PKP4 is expressed in various tissues, including the skin, heart, and reproductive organs. It is essential for maintaining tissue integrity and function, particularly in the epidermis and myocardium. Further research on the functions and mechanisms of PKP4 can provide valuable insights into cell adhesion and tissue development.
Source	Rabbit
Specificity	The PKP4 Antibody is capable of detecting the complete levels of endogenous PKP4.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Bovine;Sheep;
Antigen	PKP4
Application	Western blotting (WB) is typically performed at dilutions of 1:500 to 1:1000, while immunohistochemistry (IHC) is commonly conducted at dilutions of 1:50 to 1:200. For ELISA using peptides, the recommended dilutions range from 1:20000 to 1:40000. It is essential to adhere to these dilution guidelines to ensure accurate and reliable results. By following these dilution ranges, researchers can obtain robust data and ensure the optimal performance of their experiments.
Immunogen	A synthesized peptide.
MW	130 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was utilized to purify the antiserum and SulfoLink™ Coupling Resin was the perfect choice for this process. The antiserum was subjected to purification by this resin, resulting in a highly purified final product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid any instances of repeated freeze/thaw cycles, as this can compromise the integrity of the product.
Storage buffer	The Rabbit IgG is supplied in a solution containing phosphate buffered saline at a pH of 7.4, 150mM NaCl, 0.02% of the preservative sodium azide and 50% glycerol. It is recommended to store this product at -20°C for maximum stability, where it will remain stable for a period of 12 months from the date of receipt.
Target
Background	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q99569