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Rabbit Anti-Serpin A5 Polyclonal Antibody#abs134602

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Description

Catalog-specification	Delivery time	USD price
abs134602-100ug	1-2 Weeks	301.0
abs134602-50ug	1-2 Weeks	201.0

Overview
catalog	abs134602
Other names	The acrosomal serine protease inhibitor, also referred to as PAI-3 or Plasminogen Activator Inhibitor III, is a plasma serine protease inhibitor that belongs to the Serpin family. It is also known as PCI or Protein C inhibitor, and its other names include Serpin A5 and PlanH3. This protein plays a vital role in regulating various physiological processes, including blood coagulation and fibrinolysis. It is also involved in the control of angiogenesis, inflammation, and tumor progression. The IPSP or inhibitor of plasminogen activator secreted by prostate is a variant of PAI-3 that is specifically expressed in the prostate gland. PCI-B is another variant of PCI that is expressed in various tissues, including the liver, lungs, and brain. Overall, this protein is an essential protein whose functions are crucial for maintaining proper physiological balance in the body.
Source	Rabbit
Specificity	The antibody for Serpin A5 is capable of detecting total Serpin A5 present in the body. This means that it can recognize natural levels that are already in the system. If you need to know the amount of Serpin A5 in a sample, this antibody is an excellent tool to use for analysis. It's important to note that the generated content is similar in meaning to the original text, but the wording and structure have been rearranged to create a unique variation.
Species Reactivity	Human
Antigen	Serpin A5
Application	： - lot(peptide)，1:200001:40000。 - /(IF/ICC)，1:1001:500。 - (ELISA)，1:5001:1000。 - ，(IF/ICC)(ELISA)，1:1001:500。，。
Immunogen	A synthesized peptide.
MW	42 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimum quality, it is recommended to store this product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repetitive freeze/thaw cycles as this may negatively impact its effectiveness and overall performance. Please follow these storage guidelines to ensure the longevity and preservation of the product.
Storage buffer	This product consists of Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, containing 150mM NaCl and 0.02% sodium azide, as well as 50% glycerol. It should be stored at -20°C and is stable for 12 months from the date of receipt.
Target
Background	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
Tissue specificity	Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
Posttranslational modification	N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.Proteolytically cleaved. Inhibition of proteases is accompanied by formation of a stable enzyme-inhibitor complex and by degradation of the serpin to lower molecular weight derivatives. Proteolytically cleaved at the N-terminus; inhibits slightly the heparin- and thrombomodulin-enhanced rates of thrombin inhibition.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P05154