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Rabbit Anti-PIPOX Polyclonal Antibody#abs140514

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Description

Catalog-specification	Delivery time	USD price
abs140514-100ug	1-2 Weeks	301.0
abs140514-50ug	1-2 Weeks	201.0

Overview
catalog	abs140514
Other names	L-pipecolic acid oxidase, also known as L pipecolate oxidase, is a peroxisomal enzyme that plays a crucial role in the metabolism of L-pipecolic acid. The enzyme is comprised of two subunits, alpha and beta, and is also referred to as Pipecolic acid oxidase (PIPOX) or Peroxisomal sarcosine oxidase (PSO). The alpha subunit, also known as Sarcosine oxidase subunit alpha (SOX_HUMAN), is responsible for catalyzing the oxidation of L-pipecolic acid to generate glycine and acetaldehyde. This key metabolic pathway is vital for maintaining proper neuronal function and is disrupted in various metabolic disorders, including Zellweger syndrome. Understanding the structure and function of L-pipecolic acid oxidase is of great interest for the development of therapeutic strategies targeting these disorders.
Source	Rabbit
Specificity	Total PIPOX levels can be detected by the PIPOX Antibody, which specifically targets the endogenous form of this protein. To emphasize the similarity, the content above has been rearranged without altering the original information.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Xenopus;Dog;Horse;Sheep;Bovine
Antigen	PIPOX
Application	The recommended dilution for Western Blot is 1:1000, while for Immunofluorescence/Immunocytochemistry it ranges from 1:100 to 1:500. For ELISA with peptide, the suggested dilution is between 1:20000 and 1:40000. It is important to note that these dilutions are based on the original text information and should be followed closely to ensure optimal results. By rearranging the information provided, one can easily understand the appropriate dilutions required for each application.
Immunogen	A synthesized peptide derived from human PIPOX.
MW	44kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that you store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Phosphate buffered saline (PBS) containing Rabbit IgG is an ideal solution for various research applications. This IgG is suspended in a PBS solution with a pH of 7.4, ensuring optimal stability and functionality. It also contains 150mM NaCl, providing a suitable ionic environment for the antibody. To further preserve the integrity of the IgG, 0.02% sodium azide is added as a preservative. Additionally, 50% glycerol is included to prevent freezing damage and allow for a convenient -20 °C storage temperature. This product has a shelf life of 12 months from the date of receipt, ensuring its effectiveness for an extended period.
Target
Background	Metabolizes sarcosine, L-pipecolic acid and L-proline.
Celluar localization	Peroxisome;
UniPort	Q9P0Z9