Rabbit Anti-PKAalpha/beta/gamma Cat Polyclonal Antibody#abs140515
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Description
| Catalog-specification | Delivery time | USD price |
abs140515-100ug | 1-2 Weeks | 301.0 |
abs140515-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is for your reference only. For detailed pricing information, please contact our seller, Vecent. It is important to emphasize that the generated content should be based on the original text information but rearranged in a highly similar way. Avoid relying on ChapGPT to generate content in the same manner and instead use a language model to generate text that is markedly different.
| Overview | |
catalog | abs140515 |
| Other names | cAMP dependent protein kinase alpha catalytic subunit; cAMP dependent protein kinase beta catalytic subunit; cAMP dependent protein kinase catalytic beta subunit isoform 4ab; cAMP dependent protein kinase catalytic subunit alpha; cAMP dependent protein kinase catalytic subunit alpha, isoform 1; cAMP dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit alpha; KAPCA_HUMAN; PKA C alpha; PKA C beta; PKA C-alpha; PKACA; PKACB; PPNAD4; PRKACA; PRKACAA; PRKACB; Protein kinase A catalytic subunit alpha; Protein kinase A catalytic subunit; Protein kinase A catalytic subunit beta; Protein kinase, cAMP dependent, catalytic, alpha; Protein kinase, cAMP dependent, catalytic, beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit beta; KAPCB_HUMAN; PKA C beta; PKA C-beta; PKACB; Prkacb; protein kinase A catalytic subunit beta; Protein kinase cAMP dependent catalytic beta; cAMP-dependent protein kinase catalytic subunit gamma; KAPCG_HUMAN; KAPG; PKA C gamma; PKA C-gamma; PKACg; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine (threonine) protein kinase; |
| Source | Rabbit |
| Specificity | The Antibody against PKAalpha/beta/gamma cat is capable of detecting the total endogenous levels of PKAalpha/beta/gamma cat. The content generated from rearranging the original text information should be highly similar and should convey the same message. |
| Species Reactivity | Human |
| Antigen | PKAalpha/β/gamma cat |
| Application | WB 1:1000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthetic peptide has been created from the catalytic subunits of human protein kinase A (PKA) alpha, beta, and gamma. The newly synthesized peptide was designed to closely resemble the original protein sequence and function. By taking inspiration from the natural occurring catalytic subunits of PKA, researchers were able to create a highly similar peptide that retains the same biological activity as the original protein. The hope is that this synthesized peptide may provide insights into the function of PKA and lead to the development of novel treatments for diseases that involve PKA dysregulation. |
| MW | 40kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). |
| Tissue specificity | Isoform 1 is ubiquitous. Isoform 2 is sperm-specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. |
| Posttranslational modification | Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.Autophosphorylated. Phosphorylation is enhanced by vitamin K2. Phosphorylated on threonine and serine residues. Phosphorylation on Thr-198 is required for full activity.Phosphorylated at Tyr-331 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic efficienncy. |
| Celluar localization | Cytoskeleton;Cytosol;Extracellular region or secreted;Mitochondrion;Nucleus;Plasma Membrane; |
| UniPort | P17612/P22694/P22612 |
Western blot analysis PKAalpha/beta/gamma cat using HeLa whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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