enLanguage
Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details
Phospho-SREBP-2 (Ser455) Rabbit Polyclonal Antibody#abs140149

Phospho-SREBP-2 (Ser455) Rabbit Polyclonal Antibody#abs140149

Please note that the price provided is for your reference only. For detailed pricing information, we advise you to contact our seller, Vecent. Thank you. Western blot analysis SREBP-2 (Phospho-Ser455) using HepG2 whole cell lysates This product is for research use only, not for use in diagnostic...

Send Inquiry

Description

Catalog-specificationDelivery timeUSD price

abs140149-100ug

1-2 Weeks

301.0

abs140149-50ug

1-2 Weeks

201.0

Please note that the price provided is for your reference only. For detailed pricing information, we advise you to contact our seller, Vecent. Thank you.


Overview

catalog

abs140149
Other namesClass D basic helix-loop-helix protein 2, also known as bHLHd2, is a crucial protein involved in regulating cholesterol metabolism. It plays a significant role in the transcriptional control of genes related to cholesterol synthesis and uptake. The gene encoding this protein is called SREBF2, which stands for sterol regulatory element-binding transcription factor 2.
SREBF2 is responsible for processing and activating sterol regulatory element-binding protein 2 (SREBP-2) in the cell nucleus. SREBP-2 is a key regulator of cholesterol homeostasis, promoting the synthesis and uptake of cholesterol when cellular levels are low.
This protein, SREBF2, is also known as processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, Srebf2, SREBP 2, SREBP-2, SREBP2gc, sterol regulatory element binding factor 2, sterol regulatory element binding protein 2, or sterol regulatory element-binding transcription factor 2.
In summary, bHLHd2, or Class D basic helix-loop-helix protein 2, encoded by the SREBF2 gene, is a crucial factor involved in cholesterol metabolism, functioning through the processing and activation of SREBP-2 to maintain cellular cholesterol homeostasis.
SourceRabbit
SpecificityThe SREBP-2 (Phospho-Ser455) Antibody is capable of detecting the presence of phosphorylated SREBP-2 at Ser455. This antibody specifically targets the endogenous levels of SREBP-2 when it is in a phosphorylated state. By recognizing the phosphorylation of SREBP-2 at Ser455, this antibody enables the detection and analysis of this specific protein modification. Its ability to selectively detect this phosphorylated form of SREBP-2 provides valuable insights into the regulatory mechanisms and functional implications of SREBP-2 in various biological processes.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesZebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
AntigenSREBP-2
ApplicationWB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
ImmunogenSREBP-2（455）。，。，ChapGPT，。
MW124kDa
Properties

Concentration

1mg/ml

purificationThe purified rabbit serum underwent affinity purification using phospho- and non-phospho-peptide affinity columns to obtain the antibody. This sequential chromatography process was employed for purification.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

Tissue specificityUbiquitously expressed in adult and fetal tissues.
Posttranslational modificationAt low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression.
Celluar localizationCytosol;Endoplasmic reticulum;Golgi apparatus;Mitochondrion;Nucleus;
UniPortQ12772


Western blot analysis SREBP-2 (Phospho-Ser455) using HepG2 whole cell lysates


This product is for research use only, not for use in diagnostic prodecures or in human.


Hot Tags: phospho-srebp-2 (ser455) rabbit polyclonal antibody#abs140149, China phospho-srebp-2 (ser455) rabbit polyclonal antibody#abs140149 suppliers

You Might Also Like

Shopping Bags