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Phospho-STF-1 (Ser203) Rabbit Polyclonal Antibody#abs140151

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Description

Catalog-specification	Delivery time	USD price
abs140151-100ug	1-2 Weeks	301.0
abs140151-50ug	1-2 Weeks	201.0

Overview
catalog	abs140151
Other names	SF-1, also known as Adrenal 4-binding protein or Fushi tarazu factor homolog 1, is a nuclear receptor that plays a crucial role in the regulation of steroid hormone synthesis. It is encoded by the NR5A1 gene and is commonly referred to as FTZ1 or ELP. SF-1 is involved in the development and function of the adrenal gland, as well as other endocrine organs such as the gonads and hypothalamus. The SF-1 protein binds to specific DNA sequences and acts as a transcription factor, activating the expression of genes involved in steroidogenesis and sexual development. It is essential for the production of adrenal and gonadal steroids, including cortisol, aldosterone, and sex hormones. SF-1 also has a role in the development of the reproductive system and the regulation of reproductive functions. Mutations in the NR5A1 gene can lead to disorders of sexual development, such as XY gonadal dysgenesis and adrenal insufficiency. These conditions are characterized by impaired steroidogenesis and abnormal development of the reproductive system. SF-1 is therefore considered a key regulator of sexual development and steroid hormone production. In conclusion, SF-1, also known as Ad4BP or Fushi tarazu factor homolog 1, is a critical nuclear receptor involved in the regulation of steroid hormone synthesis and sexual development. Its role in the development and function of endocrine organs highlights its importance in maintaining hormonal balance and reproductive health.
Source	Rabbit
Specificity	The STF-1 (Phospho-Ser203) Antibody specifically recognizes the phosphorylated form of endogenous STF-1 protein at Ser203 residue. Any unphosphorylated STF-1 protein will not be detected by this antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	STF-1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A peptide that has been synthesized from Phospho-Ser203 of human STF-1 is available. You can expect the content to closely resemble the original text by rearranging the given words. However, it is important to note that the generated content should be unique and different from ChapGPT generated content.
MW	51 kDa
Properties
Concentration	1mg/ml
purification	The purification process for obtaining the antibody involved the use of affinity chromatography on both phospho- and non-phospho-peptide columns, followed by sequential purification steps. The antibody was finally obtained from purified serum collected from a rabbit.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Tissue specificity	High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).
Posttranslational modification	Acetylation stimulates the transcriptional activity.Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity.
Celluar localization	Nucleus;
UniPort	Q13285