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Phospho-Tel (Ser257) Rabbit Polyclonal Antibody#abs140154

Description

Catalog-specification	Delivery time	USD price
abs140154-100ug	1-2 Weeks	301.0
abs140154-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140154
Other names	The protein Tel1, also known as ETS translocation variant 6 or Ets variant 6, is an ETS-related protein. It is encoded by the ETV6 gene, which is also referred to as the TEL oncogene. Tel1 plays a crucial role in various cellular processes. Additionally, it is implicated in chromosomal translocations, such as TEL/ABL fusion, which can result in oncogenic transformation. Tel1 is a transcription factor and is often denoted by its protein symbol ETV6. This protein has significant implications in gene regulation and cellular functions. Its study contributes to our understanding of transcriptional regulation and its relevance in physiological and pathological conditions.
Source	Rabbit
Specificity	The Tel (Phospho-Ser257) Antibody specifically recognizes Tel protein in its phosphorylated form at Ser257. It is designed to detect the naturally occurring levels of Tel only when it is phosphorylated at this specific site.
Species Reactivity	Human
Predictive reaction species	Chicken;Dog;
Antigen	Tel
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	One potential description for a synthesized peptide derived from human Tel (Phospho-Ser257) could be the creation of a peptide molecule that is structurally similar to the human Tel protein. This molecule may have been modified to include a phosphorylated serine residue at position 257, which is known to play a critical role in Tel-mediated signaling pathways. By synthesizing a peptide with this modification, scientists may be able to gain new insights into the function of Tel and its involvement in various cellular processes. Such peptides could be used in a variety of experimental settings, including in vitro assays and in vivo studies in animal models. Overall, the creation of a synthesized peptide based on human Tel (Phospho-Ser257) may hold promise for advancing our understanding of this critical protein and its role in human health and disease.
MW	53 KD
Properties
Concentration	1mg/ml
purification	The process involved in obtaining the antibody included purifying rabbit serum and then subjecting it to affinity purification. This purification was achieved by performing sequential chromatography using phospho- and non-phospho-peptide affinity columns.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage at -20 °C is recommended to preserve the product quality. It is crucial to avoid subjecting the product to repeated freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Tissue specificity	Ubiquitous.
Posttranslational modification	Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
Celluar localization	Cytosol;Nucleus;
UniPort	P41212