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Rabbit Anti-CXCR3 Polyclonal Antibody#abs132721

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Description

Catalog-specification	Delivery time	USD price
abs132721-50ug	1-2 Weeks	201.0
abs132721-100ug	1-2 Weeks	301.0

Overview
catalog	abs132721
Description	This receptor is crucial for the proliferation of human mesangial cells (HMC) and is activated by CXCL9, CXCL10, and CXCL11. Isoform 2 is a variant of the receptor that not only binds to CXCL4 but also inhibits the growth of human microvascular endothelial cells (HMVEC) when activated by CXCL9, CXCL10, and CXCL11. Furthermore, this receptor may play a role in angiogenesis. Finally, isoform 3 mediates the activity of CXCL11 and is yet another important element of this multifaceted receptor.
Other names	Chemokine (C-X-C motif) receptor 3, also known as CD183 or CD182, is a protein that plays a crucial role in immune system function. It is a G-protein coupled receptor, specifically G protein-coupled receptor 9 (GPR9), and is involved in the response to chemokines. The chemokine receptor 3 is also referred to as CKR L2, CKR-L2, CKRL2, CMKAR3, CXC-R3, CXCR-3, CXCR3, CXCR3_HUMAN, IP-10 receptor, or Mig receptor. It is known for its affinity towards interferon-inducible protein 10 (IP-10) and monokine induced by gamma interferon (Mig). The diverse names reflect the different ways this important receptor has been characterized and researched in various studies. Its involvement in immune responses and inflammation make it an attractive therapeutic target for various diseases, including autoimmune disorders and cancer. Due to its versatile nature and varied functions, chemokine receptor 3 has garnered significant attention in the field of immunology. Better understanding of its role and signaling pathways will pave the way for the development of novel therapeutics and interventions.
Source	Rabbit
Specificity	The detection of total CXCR3 is achieved by utilizing the CXCR3 antibody, which can accurately identify the endogenous levels of CXCR3. To create a highly similar but rearranged content based on the original text information, one possible rendition could be: Utilizing the CXCR3 antibody, endogenous levels of total CXCR3 are effectively detected. This antibody specifically targets CXCR3, allowing for the identification of its natural levels within the system.
Species Reactivity	Human;Mouse;Rat
Antigen	CXCR3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	41 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. Let me provide you with alternative content that is based on the original information, while ensuring a highly similar meaning.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Tissue specificity	Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Posttranslational modification	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.N-glycosylated.
Celluar localization	Plasma Membrane;
UniPort	P49682