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Rabbit Anti-CCL24 Polyclonal Antibody#abs132642

Please note that the price provided above is for your reference only. To obtain detailed pricing information, we kindly request you to contact our seller, Vecent. Thank you. Western blot analysis of CCL24 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific...

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Description

Catalog-specification	Delivery time	USD price
abs132642-50ug	1-2 Weeks	201.0
abs132642-100ug	1-2 Weeks	301.0

Please note that the price provided above is for your reference only. To obtain detailed pricing information, we kindly request you to contact our seller, Vecent. Thank you.

Overview
catalog	abs132642
Description	This substance is a chemotactic agent that attracts resting T-lymphocytes and eosinophils, while having a lower chemotactic effect on neutrophils. It does not attract monocytes or activated lymphocytes. Interestingly, this substance has been found to strongly inhibit the formation of colonies by a multipotential hematopoietic progenitor cell line. It is known to bind to CCR3, and these properties make it a valuable tool in studying immune responses and related processes.
Other names	Chemokine CC Motif Ligand 24, also known as C-C motif chemokine 24 (CCL24), is a protein that plays a crucial role in immune response regulation. It is encoded by the CCL24 gene in humans. CCL24 is also referred to as Eotaxin-2 or Myeloid progenitor inhibitory factor 2 (MPIF-2). It belongs to the small inducible cytokine subfamily A (Cys-Cys) and is a member of the chemokine family. CCL24, also called CK beta 6 or CK-beta-6, is primarily known for its ability to attract eosinophils, a type of white blood cell involved in inflammatory responses, to the site of inflammation. It acts as a chemoattractant for eosinophils by binding to specific receptors on their cell surface. The expression of CCL24 is induced by various factors, including cytokines and allergens. It is produced by different cells and tissues, including airway epithelial cells, smooth muscle cells, and fibroblasts. Elevated levels of CCL24 have been observed in conditions such as asthma, allergic rhinitis, and eosinophilic esophagitis, where eosinophils play a significant role. CCL24 is involved not only in chemotaxis but also in other biological processes, including the activation and proliferation of eosinophils. It can also contribute to the recruitment of other immune cells, including T cells and monocytes, to the inflamed tissue. Understanding the function and regulation of CCL24 is important for developing therapeutic strategies targeting eosinophilic inflammation. Targeting CCL24 or its receptors may provide a way to modulate eosinophilic responses and alleviate the symptoms associated with eosinophil-mediated diseases. In conclusion, CCL24, also known as Eotaxin-2 or MPIF-2, is a chemokine that plays a crucial role in eosinophil recruitment and inflammation. It is involved in various immune processes and is an important target for the development of therapeutic interventions in eosinophilic disorders.
Source	Rabbit
Specificity	The CCL24 antibody has the ability to identify and measure the total quantity of endogenous CCL24. This means that it can accurately detect the levels of CCL24 already present within the system.
Species Reactivity	Human;Rat
Antigen	CCL24
Application	For Western Blot, the recommended dilution range is 1:500-1:2000. When performing Immunohistochemistry, the ideal dilution range is between 1:50 and 1:200. For ELISA using a peptide, it is recommended to use a dilution ranging from 1:20000 to 1:40000. These recommended dilution ratios have been tested and found to yield accurate results in a variety of experimental conditions. Proper dilution of primary antibodies is crucial for obtaining reliable and reproducible results. It is important to note that optimal dilutions may vary depending on the sample type and experimental conditions, so it is recommended to conduct a preliminary experiment to determine the optimal dilution for your specific experiment. With the right dilutions, you can ensure highly specific and sensitive detection of your target protein or peptide.
Immunogen	A synthesized peptide.
MW	13 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	20°C。/。
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
Tissue specificity	Activated monocytes and activated T lymphocytes.
Posttranslational modification	N-glycosylated.
Celluar localization	Extracellular region or secreted;
UniPort	O00175