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Rabbit Anti-Calsenilin/KCNIP3 Polyclonal Antibody#abs131423

Attention: the price only for your reference, the detail price please contact our seller Vecent. Western blot analysis of Calsenilin/KCNIP3 expression in A431 cells This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs131423-50ug	1-2 Weeks	201.0
abs131423-100ug	1-2 Weeks	301.0

Attention: the price only for your reference, the detail price please contact our seller Vecent.

Overview
catalog	abs131423
Description	The binding of calcium triggers a decrease in the affinity of a transcriptional repressor known to regulate genes such as PDYN and FOS. Interestingly, this repressor shows a higher affinity for DNA when bound to magnesium. It appears to be involved in the sensation of pain, suggesting a role in nociception. To summarize, this calcium-dependent repressor binds to the DRE element of various genes, exhibits altered DNA binding affinity in the presence of calcium and magnesium, and likely contributes to nociception.
Other names	Calsenilin, also known as A-type potassium channel modulatory protein 3 or DRE-antagonist modulator, is an EF hand transcription factor that interacts with potassium channels. It is encoded by the gene 4933407H12Rik and also known as KChIP3 or Kv channel-interacting protein 3. Calsenilin plays a role in modulating A-type potassium channels and is implicated in various cellular processes such as neuronal excitability, synaptic plasticity, and memory formation. Additionally, Calsenilin has been linked to neurodegenerative diseases and may have therapeutic potential for the treatment of Alzheimer's disease. Its human homolog is known as CSEN or KCNIP 3. Other aliases include DREAM, MGC18289, and R74849.
Source	Rabbit
Specificity	The Calsenilin/KCNIP3 Antibody is designed to recognize total levels of endogenous Calsenilin/KCNIP3 in various samples.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse
Antigen	Calsenilin/KCNIP3
Application	： - Western Blot（）：1:5001:2000，。 - （IHC）：1:501:200，。 - （IF）：1:1001:500，。 - （ELISA，）：1:200001:40000，。，，。，。
Immunogen	Calsenilin/KCNIP3 is a human protein that serves as a precursor for a synthesized peptide. This peptide is derived from the amino acid sequence of Calsenilin/KCNIP3 and has a high level of similarity to the original protein. The synthesized peptide obtained by rearranging the original content provides a way to study the functions and properties of Calsenilin/KCNIP3 in various biological processes. Its design is based on the information contained within the original text, ensuring that it maintains the essential characteristics and features of the protein. By exploring this synthesized peptide, researchers can gain further insights into the role of Calsenilin/KCNIP3 in cellular processes and potentially discover new therapeutic applications.
MW	29 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography during the purification process of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Tissue specificity	Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
Posttranslational modification	Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity).Proteolytically cleaved by caspase-3.Phosphorylation at Ser-63 inhibits cleavage by CASP3.
Celluar localization	Cytosol;Endoplasmic reticulum;Golgi apparatus;Nucleus;Plasma Membrane;
UniPort	Q9Y2W7