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Rabbit Anti-CCL23 Polyclonal Antibody#abs132641

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Description

Catalog-specification	Delivery time	USD price
abs132641-100ug	1-2 Weeks	301.0
abs132641-50ug	1-2 Weeks	201.0

Overview
catalog	abs132641
Description	This protein exhibits chemotactic activity towards monocytes, neutrophils, and resting T-lymphocytes, but not activated lymphocytes. Its ability to inhibit proliferation of myeloid progenitor cells has been demonstrated in colony formation assays. It has been found to bind heparin, and it binds to CCR1. Interestingly, CCL23(19-99), CCL23(22-99), CCL23(27-99), and CCL23(30-99) have been shown to be more potent chemoattractants than small-inducible cytokine A23. These findings suggest the importance of this protein in the immune response, particularly in the recruitment of immune cells to sites of inflammation.
Other names	CC motif chemokine ligand 23, also known as CCL23 or MIP-3, is a small inducible cytokine belonging to the C-C motif chemokine family. It is also referred to as C6 beta chemokine, Hmrp-2a, MPIF-1, or SCYA23. CCL23 is produced by various cell types, including monocytes, macrophages, and dendritic cells, during times of infection or inflammation. Its role is to attract and activate immune cells, such as T cells and dendritic cells, to the site of inflammation. CCL23 has been implicated in various inflammatory disorders, including asthma, allergic rhinitis, and rheumatoid arthritis, making it a potential target for therapeutic interventions.
Source	Rabbit
Specificity	The CCL23 antibody has the capability to identify the total amount of CCL23 that already exists within the body. This implies that it has the ability to detect the endogenous levels of CCL23 without any interference or disturbance. Therefore, the CCL23 antibody serves as a useful tool in various research fields where the study of CCL23 is required.
Species Reactivity	Human;Mouse
Antigen	CCL23
Application	The recommended dilutions for using this antibody in various applications are as follows: for Western Blotting, a dilution of 1:500 to 1:2000 is suggested, for Immunohistochemistry, a dilution of 1:50 to 1:200 is advised, and for ELISA with peptide, a dilution of 1:20000 to 1:40000 is recommended. These dilutions have been optimized for maximum specificity and sensitivity and represent the best starting points for experimentation. It should be noted that the optimal dilution may vary depending on the specific application and experimental conditions.
Immunogen	A synthesized peptide.
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
Tissue specificity	High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
Celluar localization	Extracellular region or secreted;
UniPort	P55773