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Rabbit Anti-CXCR5 Polyclonal Antibody#abs132722

Description

Catalog-specification	Delivery time	USD price
abs132722-100ug	In Stock	301.0
abs132722-50ug	In Stock	201.0

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Overview
catalog	abs132722
Description	The receptor for B-lymphocyte chemoattractant (BLC) is a cytokine receptor that plays a crucial role in the migration of B cells into the B-cell follicles of the spleen and Peyer patches. However, it is not involved in the migration of B cells into the B-cell follicles of mesenteric or peripheral lymph nodes. This receptor may have a regulatory function in the development of Burkitt lymphoma (BL) and the differentiation of B cells. Its role in these processes suggests its potential significance as a target for therapeutic interventions in BL and other related lymphomas.
Other names	Burkitt lymphoma receptor 1 (BLR1), also known as CD185 or C-X-C chemokine receptor type 5 (CXCR5), is a GTP binding protein involved in the regulation of immune responses. It is a receptor for chemokines belonging to the C-X-C motif family. BLR1 is also referred to as MDR15 or monocyte-derived receptor 15. The protein plays a crucial role in the migration and positioning of immune cells. It functions as a signaling molecule, transmitting signals from chemokines to the cell interior, leading to various cellular responses. Additionally, BLR1 is implicated in Burkitt lymphoma, a type of cancer affecting B lymphocytes, and its expression has been observed in other malignancies as well.
Source	Rabbit
Specificity	The total amount of CXCR5 present in the system can be accurately determined by using the CXCR5 antibody, which specifically targets and identifies the endogenous levels of CXCR5.
Species Reactivity	Human;Mouse;Rat
Antigen	CXCR5
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	42 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. Our approach resulted in a highly effective and specific method for purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Tissue specificity	Expression in mature B-cells and Burkitt lymphoma cells.
Celluar localization	Plasma Membrane;
UniPort	P32302