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Rabbit Anti-CXCR6 Polyclonal Antibody#abs132723

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis of CXCR6 expression in HEK293 cells ,The lane on the left is treated with the antigen-specific peptide....

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Description

Catalog-specification	Delivery time	USD price
abs132723-100ug	In Stock	301.0
abs132723-50ug	In Stock	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs132723
Description	The CXCL16 chemokine binds to a specific receptor, known as C-X-C chemokine receptor CXCR6. This receptor is utilized by several viruses, including SIVs, HIV-2 strains, and certain variants of m-tropic HIV-1, as a co-receptor. The CXCR6 receptor plays a crucial role in the process of viral entry into target cells. Its identification and characterization have provided important insights into the mechanisms underlying viral pathogenesis and have led to the development of novel therapeutic approaches.
Other names	Chemokine Receptor Type 6, also known as CXCR6 or CD186, is a G protein-coupled receptor involved in immune response and cell migration. This receptor, also referred to as CDw186 or CXCR6 antigen, plays a crucial role in inflammation and the trafficking of immune cells. It is classified as a C-X-C chemokine receptor and is responsible for binding chemokines with a C-X-C motif, particularly the ligand CXCL16. CXCR6 is implicated in various diseases including cancer, HIV infection, and autoimmune disorders. Its signaling pathway is intricately involved in regulating immune cell recruitment and activation. Overall, CXCR6 is a critical receptor for immune system function and a potential target for therapeutic interventions.
Source	Rabbit
Specificity	Total CXCR6 levels in the body can be detected using CXCR6 antibody. This antibody is effective in recognizing endogenous CXCR6, thereby allowing accurate measurement of the overall expression of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	CXCR6
Application	The dilution ratios for WB, IHC, and ELISA (peptide) are as follows: WB is diluted at a ratio of 1:500-1:2000, IHC at a ratio of 1:50-1:100, and ELISA (peptide) at a ratio of 1:20000-1:40000.
Immunogen	A synthesized peptide.
MW	44 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was accomplished through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Tissue specificity	Expressed in lymphoid tissues and activated T cells.
Celluar localization	Plasma Membrane;
UniPort	O00574